Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2008.06.046
DC FieldValue
dc.titleRole of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells
dc.contributor.authorYamamura, Y.
dc.contributor.authorLee, W.L.
dc.contributor.authorGoh, M.X.
dc.contributor.authorIto, Y.
dc.date.accessioned2011-09-27T05:44:38Z
dc.date.available2011-09-27T05:44:38Z
dc.date.issued2008
dc.identifier.citationYamamura, Y., Lee, W.L., Goh, M.X., Ito, Y. (2008). Role of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells. FEBS Letters 582 (17) : 2663-2667. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2008.06.046
dc.identifier.issn00145793
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/27092
dc.description.abstractTransforming growth factor-β (TGF-β) is implicated as a tumor suppressor because it eliminates cancer cells from normal tissues by inhibiting cell growth and inducing apoptosis. Although p53 tumor suppressor is required for TGF-β-induced p21WAF1 expression and cell growth inhibition, its role in TGF-β-induced apoptosis remains unclear. Here, we report that TAp73α, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic Bax and Puma to activate their transcription, and mediates TGF-β-induced apoptosis in gastric cancer cells. Our findings reveal a novel role of TAp73α in the induction of apoptosis by TGF-β in cancer cells. © 2008 Federation of European Biochemical Societies.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.febslet.2008.06.046
dc.sourceScopus
dc.subjectApoptosis
dc.subjectGastric cancer
dc.subjectp73
dc.subjectTGF-β
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1016/j.febslet.2008.06.046
dc.description.sourcetitleFEBS Letters
dc.description.volume582
dc.description.issue17
dc.description.page2663-2667
dc.identifier.isiut000258112000032
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