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https://doi.org/10.1016/j.peptides.2007.05.009
| Title: | Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model | Authors: | Joseph, T. Lee, T.-L. Li, C. Siau, C. Tachibana, S. Nishiuchi, Y. Kimura, T. |
Keywords: | Neuropathic pain Nociceptin/orphanin FQ Nocistatin Prepronociceptin Radioimmunoassay |
Issue Date: | 2007 | Citation: | Joseph, T., Lee, T.-L., Li, C., Siau, C., Tachibana, S., Nishiuchi, Y., Kimura, T. (2007). Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model. Peptides 28 (7) : 1433-1440. ScholarBank@NUS Repository. https://doi.org/10.1016/j.peptides.2007.05.009 | Abstract: | Neuropeptides nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are related to pain modulation. The amounts of these peptides and their precursor protein, prepronociceptin (ppN/OFQ) in the brain, spinal cord and serum samples of rats with partial sciatic nerve ligation (PSNL) were compared with those in naïve rats using radioimmunoassay (RIA). There was a significant rise in the levels of ppN/OFQ, N/OFQ and NST in the brains of PSNL rats. Their spinal cords showed significantly increased ppN/OFQ and NST levels but no change in N/OFQ levels. The PSNL rats also had increased serum NST (statistically significant) and N/OFQ (statistically insignificant) with decreased ppN/OFQ suggesting important roles of these peptides in neuropathic pain mechanism. © 2007 Elsevier Inc. All rights reserved. | Source Title: | Peptides | URI: | http://scholarbank.nus.edu.sg/handle/10635/26190 | ISSN: | 01969781 | DOI: | 10.1016/j.peptides.2007.05.009 |
| Appears in Collections: | Staff Publications |
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