Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.peptides.2007.05.009
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dc.titleLevels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model
dc.contributor.authorJoseph, T.
dc.contributor.authorLee, T.-L.
dc.contributor.authorLi, C.
dc.contributor.authorSiau, C.
dc.contributor.authorTachibana, S.
dc.contributor.authorNishiuchi, Y.
dc.contributor.authorKimura, T.
dc.date.accessioned2011-09-19T04:47:40Z
dc.date.available2011-09-19T04:47:40Z
dc.date.issued2007
dc.identifier.citationJoseph, T., Lee, T.-L., Li, C., Siau, C., Tachibana, S., Nishiuchi, Y., Kimura, T. (2007). Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model. Peptides 28 (7) : 1433-1440. ScholarBank@NUS Repository. https://doi.org/10.1016/j.peptides.2007.05.009
dc.identifier.issn01969781
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26190
dc.description.abstractNeuropeptides nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are related to pain modulation. The amounts of these peptides and their precursor protein, prepronociceptin (ppN/OFQ) in the brain, spinal cord and serum samples of rats with partial sciatic nerve ligation (PSNL) were compared with those in naïve rats using radioimmunoassay (RIA). There was a significant rise in the levels of ppN/OFQ, N/OFQ and NST in the brains of PSNL rats. Their spinal cords showed significantly increased ppN/OFQ and NST levels but no change in N/OFQ levels. The PSNL rats also had increased serum NST (statistically significant) and N/OFQ (statistically insignificant) with decreased ppN/OFQ suggesting important roles of these peptides in neuropathic pain mechanism. © 2007 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.peptides.2007.05.009
dc.sourceScopus
dc.subjectNeuropathic pain
dc.subjectNociceptin/orphanin FQ
dc.subjectNocistatin
dc.subjectPrepronociceptin
dc.subjectRadioimmunoassay
dc.typeArticle
dc.contributor.departmentANAESTHESIA
dc.description.doi10.1016/j.peptides.2007.05.009
dc.description.sourcetitlePeptides
dc.description.volume28
dc.description.issue7
dc.description.page1433-1440
dc.identifier.isiut000248972600013
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