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|Title:||Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model|
|Authors:||Joseph, T. |
|Citation:||Joseph, T., Lee, T.-L., Li, C., Siau, C., Tachibana, S., Nishiuchi, Y., Kimura, T. (2007). Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model. Peptides 28 (7) : 1433-1440. ScholarBank@NUS Repository. https://doi.org/10.1016/j.peptides.2007.05.009|
|Abstract:||Neuropeptides nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are related to pain modulation. The amounts of these peptides and their precursor protein, prepronociceptin (ppN/OFQ) in the brain, spinal cord and serum samples of rats with partial sciatic nerve ligation (PSNL) were compared with those in naïve rats using radioimmunoassay (RIA). There was a significant rise in the levels of ppN/OFQ, N/OFQ and NST in the brains of PSNL rats. Their spinal cords showed significantly increased ppN/OFQ and NST levels but no change in N/OFQ levels. The PSNL rats also had increased serum NST (statistically significant) and N/OFQ (statistically insignificant) with decreased ppN/OFQ suggesting important roles of these peptides in neuropathic pain mechanism. © 2007 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Staff Publications|
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