Please use this identifier to cite or link to this item:
|Title:||Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model|
|Authors:||Joseph, T. |
|Citation:||Joseph, T., Lee, T.-L., Li, C., Siau, C., Tachibana, S., Nishiuchi, Y., Kimura, T. (2007). Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model. Peptides 28 (7) : 1433-1440. ScholarBank@NUS Repository. https://doi.org/10.1016/j.peptides.2007.05.009|
|Abstract:||Neuropeptides nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are related to pain modulation. The amounts of these peptides and their precursor protein, prepronociceptin (ppN/OFQ) in the brain, spinal cord and serum samples of rats with partial sciatic nerve ligation (PSNL) were compared with those in naïve rats using radioimmunoassay (RIA). There was a significant rise in the levels of ppN/OFQ, N/OFQ and NST in the brains of PSNL rats. Their spinal cords showed significantly increased ppN/OFQ and NST levels but no change in N/OFQ levels. The PSNL rats also had increased serum NST (statistically significant) and N/OFQ (statistically insignificant) with decreased ppN/OFQ suggesting important roles of these peptides in neuropathic pain mechanism. © 2007 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 17, 2018
WEB OF SCIENCETM
checked on Jun 26, 2018
checked on Jun 2, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.