Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.peptides.2007.05.009
Title: Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model
Authors: Joseph, T. 
Lee, T.-L. 
Li, C. 
Siau, C.
Tachibana, S. 
Nishiuchi, Y.
Kimura, T.
Keywords: Neuropathic pain
Nociceptin/orphanin FQ
Nocistatin
Prepronociceptin
Radioimmunoassay
Issue Date: 2007
Source: Joseph, T., Lee, T.-L., Li, C., Siau, C., Tachibana, S., Nishiuchi, Y., Kimura, T. (2007). Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model. Peptides 28 (7) : 1433-1440. ScholarBank@NUS Repository. https://doi.org/10.1016/j.peptides.2007.05.009
Abstract: Neuropeptides nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are related to pain modulation. The amounts of these peptides and their precursor protein, prepronociceptin (ppN/OFQ) in the brain, spinal cord and serum samples of rats with partial sciatic nerve ligation (PSNL) were compared with those in naïve rats using radioimmunoassay (RIA). There was a significant rise in the levels of ppN/OFQ, N/OFQ and NST in the brains of PSNL rats. Their spinal cords showed significantly increased ppN/OFQ and NST levels but no change in N/OFQ levels. The PSNL rats also had increased serum NST (statistically significant) and N/OFQ (statistically insignificant) with decreased ppN/OFQ suggesting important roles of these peptides in neuropathic pain mechanism. © 2007 Elsevier Inc. All rights reserved.
Source Title: Peptides
URI: http://scholarbank.nus.edu.sg/handle/10635/26190
ISSN: 01969781
DOI: 10.1016/j.peptides.2007.05.009
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

9
checked on Nov 20, 2017

Page view(s)

209
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.