Please use this identifier to cite or link to this item:
Title: Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium
Authors: Yap, S.P.
Shen, P. 
Li, J. 
Yong, E.L. 
Lee, L.S.
Keywords: Epimedium
Estradiol valerate
Estrogenic activity
Issue Date: 2007
Citation: Yap, S.P., Shen, P., Li, J., Yong, E.L., Lee, L.S. (2007). Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. Journal of Ethnopharmacology 113 (2) : 218-224. ScholarBank@NUS Repository.
Abstract: The Chinese medicinal herb, Epimedium, used traditionally for bone health exerts estrogenic activity (EA) in vitro. A genetically characterized Epimedium brevicornum (EB) extract induced biphasic responses in the mRNA and protein expression of the estrogen-regulated progesterone receptor gene in breast cancer (MCF-7) cells. These changes were mirrored changes in estrogenic receptor (ERα) content. In male Sprague-Dawley rats, administration of the estrogenic prodrug, estradiol valerate increased area-under-curve of serum effects for ERα (AUC difference: 18,900EA(ERα) min; 95% CI: 0-37,800; p = 0.05) and breast cancer cell (MCF-7) growth (AUC difference: 30,200EA(MCF-7) min; 95% CI: 24,200-36,200; p < 0.001), compared to placebo. Oral administration of Epimedium brevicornum increased ERα activity (1320EA(ERα) min, p < 0.01). Our data indicate that estrogen-responsive bioassays can measure the pharmacokinetic/pharmacodynamics of estrogenic activity in serum. Epimedium brevicornum extract increases estrogenic activity in serum and human studies are required to evaluate whether Epimedium extracts have utility for estrogen replacement therapy. © 2007 Elsevier Ireland Ltd. All rights reserved.
Source Title: Journal of Ethnopharmacology
ISSN: 03788741
DOI: 10.1016/j.jep.2007.05.029
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 16, 2022


checked on Jan 6, 2022

Page view(s)

checked on Jan 13, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.