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https://doi.org/10.1016/j.jep.2007.05.029
Title: | Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium | Authors: | Yap, S.P. Shen, P. Li, J. Yong, E.L. Lee, L.S. |
Keywords: | Epimedium Estradiol valerate Estrogenic activity Pharmacodynamic Rat |
Issue Date: | 2007 | Citation: | Yap, S.P., Shen, P., Li, J., Yong, E.L., Lee, L.S. (2007). Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. Journal of Ethnopharmacology 113 (2) : 218-224. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jep.2007.05.029 | Abstract: | The Chinese medicinal herb, Epimedium, used traditionally for bone health exerts estrogenic activity (EA) in vitro. A genetically characterized Epimedium brevicornum (EB) extract induced biphasic responses in the mRNA and protein expression of the estrogen-regulated progesterone receptor gene in breast cancer (MCF-7) cells. These changes were mirrored changes in estrogenic receptor (ERα) content. In male Sprague-Dawley rats, administration of the estrogenic prodrug, estradiol valerate increased area-under-curve of serum effects for ERα (AUC difference: 18,900EA(ERα) min; 95% CI: 0-37,800; p = 0.05) and breast cancer cell (MCF-7) growth (AUC difference: 30,200EA(MCF-7) min; 95% CI: 24,200-36,200; p < 0.001), compared to placebo. Oral administration of Epimedium brevicornum increased ERα activity (1320EA(ERα) min, p < 0.01). Our data indicate that estrogen-responsive bioassays can measure the pharmacokinetic/pharmacodynamics of estrogenic activity in serum. Epimedium brevicornum extract increases estrogenic activity in serum and human studies are required to evaluate whether Epimedium extracts have utility for estrogen replacement therapy. © 2007 Elsevier Ireland Ltd. All rights reserved. | Source Title: | Journal of Ethnopharmacology | URI: | http://scholarbank.nus.edu.sg/handle/10635/26009 | ISSN: | 03788741 | DOI: | 10.1016/j.jep.2007.05.029 |
Appears in Collections: | Staff Publications |
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