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|Title:||Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium|
|Citation:||Yap, S.P., Shen, P., Li, J., Yong, E.L., Lee, L.S. (2007). Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. Journal of Ethnopharmacology 113 (2) : 218-224. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jep.2007.05.029|
|Abstract:||The Chinese medicinal herb, Epimedium, used traditionally for bone health exerts estrogenic activity (EA) in vitro. A genetically characterized Epimedium brevicornum (EB) extract induced biphasic responses in the mRNA and protein expression of the estrogen-regulated progesterone receptor gene in breast cancer (MCF-7) cells. These changes were mirrored changes in estrogenic receptor (ERα) content. In male Sprague-Dawley rats, administration of the estrogenic prodrug, estradiol valerate increased area-under-curve of serum effects for ERα (AUC difference: 18,900EA(ERα) min; 95% CI: 0-37,800; p = 0.05) and breast cancer cell (MCF-7) growth (AUC difference: 30,200EA(MCF-7) min; 95% CI: 24,200-36,200; p < 0.001), compared to placebo. Oral administration of Epimedium brevicornum increased ERα activity (1320EA(ERα) min, p < 0.01). Our data indicate that estrogen-responsive bioassays can measure the pharmacokinetic/pharmacodynamics of estrogenic activity in serum. Epimedium brevicornum extract increases estrogenic activity in serum and human studies are required to evaluate whether Epimedium extracts have utility for estrogen replacement therapy. © 2007 Elsevier Ireland Ltd. All rights reserved.|
|Source Title:||Journal of Ethnopharmacology|
|Appears in Collections:||Staff Publications|
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