Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jep.2007.05.029
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dc.titleMolecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium
dc.contributor.authorYap, S.P.
dc.contributor.authorShen, P.
dc.contributor.authorLi, J.
dc.contributor.authorYong, E.L.
dc.contributor.authorLee, L.S.
dc.date.accessioned2011-09-15T08:22:00Z
dc.date.available2011-09-15T08:22:00Z
dc.date.issued2007
dc.identifier.citationYap, S.P., Shen, P., Li, J., Yong, E.L., Lee, L.S. (2007). Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. Journal of Ethnopharmacology 113 (2) : 218-224. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jep.2007.05.029
dc.identifier.issn03788741
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26009
dc.description.abstractThe Chinese medicinal herb, Epimedium, used traditionally for bone health exerts estrogenic activity (EA) in vitro. A genetically characterized Epimedium brevicornum (EB) extract induced biphasic responses in the mRNA and protein expression of the estrogen-regulated progesterone receptor gene in breast cancer (MCF-7) cells. These changes were mirrored changes in estrogenic receptor (ERα) content. In male Sprague-Dawley rats, administration of the estrogenic prodrug, estradiol valerate increased area-under-curve of serum effects for ERα (AUC difference: 18,900EA(ERα) min; 95% CI: 0-37,800; p = 0.05) and breast cancer cell (MCF-7) growth (AUC difference: 30,200EA(MCF-7) min; 95% CI: 24,200-36,200; p < 0.001), compared to placebo. Oral administration of Epimedium brevicornum increased ERα activity (1320EA(ERα) min, p < 0.01). Our data indicate that estrogen-responsive bioassays can measure the pharmacokinetic/pharmacodynamics of estrogenic activity in serum. Epimedium brevicornum extract increases estrogenic activity in serum and human studies are required to evaluate whether Epimedium extracts have utility for estrogen replacement therapy. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jep.2007.05.029
dc.sourceScopus
dc.subjectEpimedium
dc.subjectEstradiol valerate
dc.subjectEstrogenic activity
dc.subjectPharmacodynamic
dc.subjectRat
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.jep.2007.05.029
dc.description.sourcetitleJournal of Ethnopharmacology
dc.description.volume113
dc.description.issue2
dc.description.page218-224
dc.identifier.isiut000249456900005
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