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|Title:||Down regulation of immuno-detectable cardiac connexin-43 in BALB/c mice following acute fasting||Authors:||McLachlan, C.S.
|Issue Date:||2009||Citation:||McLachlan, C.S., Almsherqi, Z.A., Leong, S.T., Deng, Y., Mossop, P., Suzuki, J. (2009). Down regulation of immuno-detectable cardiac connexin-43 in BALB/c mice following acute fasting. International Journal of Cardiology 136 (1) : 99-102. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2008.03.098||Abstract:||Acute starvation effects for connexin-43 protein expression, in the heart, had not been previously explored. Hence we examined acute fasting on the myocardial immuno-histochemical expression of connexin-43 in 3 groups of 8-week old female BALB/c mice. Groups consisted of control mice (n = 5), fasting for 24 h (N = 5) and 48 h (N = 3). Under light microscopy all control fed cases revealed the presence of some immuno-detectable staining for connexin-43 that is either present or weakly observed in some or all of the regions of interest, that include the cross-sectional left ventricular sub-endocardium, mid-myocardium and papillary muscle. Whereas mice that underwent 24 or 48 h of acute starvation, connexin-43 expression was either difficult to detect visually (N = 3) or was completely absent (N = 5) at 40× magnification using a light microscope. In starved mice with no membrane staining for connexin-43 we observed an increase in the intracellular accumulation of cytoplasmic connexin-43 expression. © 2008 Elsevier Ireland Ltd. All rights reserved.||Source Title:||International Journal of Cardiology||URI:||http://scholarbank.nus.edu.sg/handle/10635/24969||ISSN:||01675273||DOI:||10.1016/j.ijcard.2008.03.098|
|Appears in Collections:||Staff Publications|
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