Please use this identifier to cite or link to this item:
Title: Down regulation of immuno-detectable cardiac connexin-43 in BALB/c mice following acute fasting
Authors: McLachlan, C.S. 
Almsherqi, Z.A. 
Leong, S.T.
Deng, Y. 
Mossop, P.
Suzuki, J.
Keywords: Acute starvation
Cardiac myocyte
Issue Date: 2009
Citation: McLachlan, C.S., Almsherqi, Z.A., Leong, S.T., Deng, Y., Mossop, P., Suzuki, J. (2009). Down regulation of immuno-detectable cardiac connexin-43 in BALB/c mice following acute fasting. International Journal of Cardiology 136 (1) : 99-102. ScholarBank@NUS Repository.
Abstract: Acute starvation effects for connexin-43 protein expression, in the heart, had not been previously explored. Hence we examined acute fasting on the myocardial immuno-histochemical expression of connexin-43 in 3 groups of 8-week old female BALB/c mice. Groups consisted of control mice (n = 5), fasting for 24 h (N = 5) and 48 h (N = 3). Under light microscopy all control fed cases revealed the presence of some immuno-detectable staining for connexin-43 that is either present or weakly observed in some or all of the regions of interest, that include the cross-sectional left ventricular sub-endocardium, mid-myocardium and papillary muscle. Whereas mice that underwent 24 or 48 h of acute starvation, connexin-43 expression was either difficult to detect visually (N = 3) or was completely absent (N = 5) at 40× magnification using a light microscope. In starved mice with no membrane staining for connexin-43 we observed an increase in the intracellular accumulation of cytoplasmic connexin-43 expression. © 2008 Elsevier Ireland Ltd. All rights reserved.
Source Title: International Journal of Cardiology
ISSN: 01675273
DOI: 10.1016/j.ijcard.2008.03.098
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jun 2, 2023


checked on Jun 2, 2023

Page view(s)

checked on May 25, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.