Please use this identifier to cite or link to this item:
Title: Analyzing COVID-19 Vaccine Responses in Transplant Recipients
Authors: Murali, TM 
Shunmuganathan, B 
Trueman, ELL 
Gupta, R 
Tan, RSW
Sran, HK 
D'Costa, MR
Wong, ETY 
Gu, Y
Cui, J 
Wee Kun, K 
Lim, AQH
Qian, X 
Purushotorman, K 
Chen, J 
MacAry, PA 
Vathsala, A 
Keywords: Humans
COVID-19 Vaccines
BNT162 Vaccine
Transplant Recipients
Issue Date: 1-Oct-2023
Publisher: The American Association of Immunologists
Citation: Murali, TM, Shunmuganathan, B, Trueman, ELL, Gupta, R, Tan, RSW, Sran, HK, D'Costa, MR, Wong, ETY, Gu, Y, Cui, J, Wee Kun, K, Lim, AQH, Qian, X, Purushotorman, K, Chen, J, MacAry, PA, Vathsala, A (2023-10-01). Analyzing COVID-19 Vaccine Responses in Transplant Recipients. ImmunoHorizons 7 (10) : 708-717. ScholarBank@NUS Repository.
Abstract: COVID-19 vaccination has significantly impacted the global pandemic by reducing the severity of infection, lowering rates of hospitalization, and reducing morbidity/mortality in healthy individuals. However, the degree of vaccine-induced protection afforded to renal transplant recipients who receive forms of maintenance immunosuppression remains poorly defined. This is particularly important when we factor in the emergence of SARS-CoV-2 variants of concern (VOCs) that have defined mutations that reduce the effectiveness of Ab responses targeting the Spike Ags from the ancestral Wuhan-Hu-1 variants employed in the most widely used vaccine formats. In this study, we describe a qualitative, longitudinal analysis of neutralizing Ab responses against multiple SARS-CoV-2 VOCs in 129 renal transplant recipients who have received three doses of the Pfizer-BioNTech COVID-19 vaccine (BNT162b2). Our results reveal a qualitative and quantitative reduction in the vaccine-induced serological response in transplant recipients versus healthy controls where only 51.9% (67 of 129) made a measurable vaccine-induced IgG response and 41.1% (53 of 129) exhibited a significant neutralizing Ab titer (based on a pseudovirus neutralization test value >50%). Analysis on the VOCs revealed strongest binding toward the wild-type Wuhan-Hu-1 and Delta variants but none with both of the Omicron variants tested (BA1 and BA2). Moreover, older transplant recipients and those who are on mycophenolic acid as part of their maintenance therapy exhibited a profound reduction in all of the analyzed vaccine-induced immune correlates. These data have important implications for how we monitor and manage transplant patients in the future as COVID-19 becomes endemic in our populations.
Source Title: ImmunoHorizons
ISSN: 2573-7732
DOI: 10.4049/immunohorizons.2300071
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Murali - Analyzing COVID-19 Vaccine Responses in Transplant Recipients (Immunohorizons 2023).pdf2.49 MBAdobe PDF



Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.