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Title: Experiment-originated variations, and multi-peak and multi-origination phenomena in derivatization-based GC-MS metabolomics
Authors: Xu, F. 
Zou, L. 
Ong, C.N. 
Keywords: Biomarker
Derivatization-based GC-MS
Experiment-derived variation
Gas chromatography
Mass spectrometry
Metabolic pathway
Multi-origination phenomena
Multi-peak phenomena
Issue Date: 2010
Citation: Xu, F., Zou, L., Ong, C.N. (2010). Experiment-originated variations, and multi-peak and multi-origination phenomena in derivatization-based GC-MS metabolomics. TrAC - Trends in Analytical Chemistry 29 (3) : 269-280. ScholarBank@NUS Repository.
Abstract: Gas chromatography combined with mass spectrometry (GC-MS), in particular derivatization-based GC-MS, is one of the most commonly used analytical methods in metabolomics. However, experiment-derived variations and originations of chromatographic peaks are two fundamental issues that could influence interpretation of metabolic pathways. Here, we focus on some pitfalls and limitations, especially the commonly ignored multi-origination and multi-peak phenomena in derivatization-based GC-MS metabolomics. We use examples to illustrate that ignoring these two factors could lead to wrong interpretations of results and serious metabolic implications. We also discuss strategies to overcome some of these confounding factors. © 2010 Elsevier Ltd. All rights reserved.
Source Title: TrAC - Trends in Analytical Chemistry
ISSN: 01659936
DOI: 10.1016/j.trac.2009.12.007
Appears in Collections:Staff Publications

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