Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.trac.2009.12.007
Title: Experiment-originated variations, and multi-peak and multi-origination phenomena in derivatization-based GC-MS metabolomics
Authors: Xu, F. 
Zou, L. 
Ong, C.N. 
Keywords: Biomarker
Derivatization-based GC-MS
Experiment-derived variation
Gas chromatography
Mass spectrometry
Metabolic pathway
Metabolomics
Metabonomics
Multi-origination phenomena
Multi-peak phenomena
Issue Date: 2010
Source: Xu, F.,Zou, L.,Ong, C.N. (2010). Experiment-originated variations, and multi-peak and multi-origination phenomena in derivatization-based GC-MS metabolomics. TrAC - Trends in Analytical Chemistry 29 (3) : 269-280. ScholarBank@NUS Repository. https://doi.org/10.1016/j.trac.2009.12.007
Abstract: Gas chromatography combined with mass spectrometry (GC-MS), in particular derivatization-based GC-MS, is one of the most commonly used analytical methods in metabolomics. However, experiment-derived variations and originations of chromatographic peaks are two fundamental issues that could influence interpretation of metabolic pathways. Here, we focus on some pitfalls and limitations, especially the commonly ignored multi-origination and multi-peak phenomena in derivatization-based GC-MS metabolomics. We use examples to illustrate that ignoring these two factors could lead to wrong interpretations of results and serious metabolic implications. We also discuss strategies to overcome some of these confounding factors. © 2010 Elsevier Ltd. All rights reserved.
Source Title: TrAC - Trends in Analytical Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/24583
ISSN: 01659936
DOI: 10.1016/j.trac.2009.12.007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

33
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

24
checked on Nov 2, 2017

Page view(s)

229
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.