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https://doi.org/10.14348/molcells.2016.2318
Title: | Sirt1 and the Mitochondria | Authors: | Tang, Bor Luen | Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Cell Biology mitochondria mitochondrial biogenesis mitophagy PGC-1 alpha Sirt1 ACTIVATED PROTEIN-KINASE EXTENDS LIFE-SPAN FOXO TRANSCRIPTION FACTORS EMBRYONIC STEM-CELLS SKELETAL-MUSCLE CALORIE RESTRICTION PARKINSONS-DISEASE HUNTINGTONS-DISEASE ALPHA-SYNUCLEIN GENE-EXPRESSION |
Issue Date: | Feb-2016 | Publisher: | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | Citation: | Tang, Bor Luen (2016-02). Sirt1 and the Mitochondria. MOLECULES AND CELLS 39 (2) : 87-95. ScholarBank@NUS Repository. https://doi.org/10.14348/molcells.2016.2318 | Abstract: | Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1’s deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1a(PGC-1α) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1’s role in caloric restriction and impacts on longevity. The notion of Sirt1’s regulation of PGC-1a activity and its role in mitochondrial biogenesis has, however, been controversial. Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy. I discuss here evidences for Sirt1’s regulation of mitochondrial biogenesis and turnover, in relation to PGC-1α deacetylation and various aspects of cellular physiology and disease. | Source Title: | MOLECULES AND CELLS | URI: | https://scholarbank.nus.edu.sg/handle/10635/245186 | ISSN: | 1016-8478 0219-1032 |
DOI: | 10.14348/molcells.2016.2318 |
Appears in Collections: | Staff Publications Elements |
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