Please use this identifier to cite or link to this item:
|Title:||The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro||Authors:||Li, L.
|Issue Date:||2007||Citation:||Li, L., Lu, J., Tay, S.S.W., He, B.P., Moochhala, S.M. (2007). The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro. Brain Research 1159 (1) : 8-17. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2007.04.066||Abstract:||Opposing functions of activated microglia, namely neuroprotection or neurotrophy versus neurodestruction or neurotoxicity, have been observed in a number of experimental models of neurotrauma and neurodegenerative diseases. However, the mechanism(s) involved in the determination of which function activated microglia execute under a given set of conditions still remains to be elucidated. Our current in vitro study has revealed that a neuroprotective/neurotrophic or a neurodestructive/neurotoxic microglial function may be configured by the equilibrium among various microglial factors released into the microenvironment. When NSC-34 neurons were treated with lower concentrations of lipopolysaccharide-stimulated BV-2 microglial conditioned medium (LPS-BVCM), viability of the NSC-34 neurons increased, outgrowth of neuronal processes was promoted, and the formation of 2,5-hexanedione-induced aggregates was prevented. However, when NSC-34 neurons were treated with higher concentrations of the same LPS-BVCM, neuronal viability was reduced, apoptosis was induced and outgrowth of neuronal processes was prevented. Measurement of the cytokines tumor necrotic factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 in the LPS-BVCM has shown that the upregulation in expression for each cytokine varied both temporally and quantitatively. It is postulated that an alteration in the concentration of the LPS-BVCM might significantly affect the functional balance of microglial factors in the microenvironment with a resultant different microglial function. © 2007 Elsevier B.V. All rights reserved.||Source Title:||Brain Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/24316||ISSN:||00068993||DOI:||10.1016/j.brainres.2007.04.066|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 10, 2019
WEB OF SCIENCETM
checked on Dec 3, 2019
checked on Dec 2, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.