Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2007.04.066
Title: The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro
Authors: Li, L. 
Lu, J. 
Tay, S.S.W. 
He, B.P. 
Moochhala, S.M. 
Keywords: 2,5-Hexanedione
Dual function
Microglia
Neurodegeneration
Neuroprotection
Neurotoxicity
Issue Date: 2007
Source: Li, L.,Lu, J.,Tay, S.S.W.,He, B.P.,Moochhala, S.M. (2007). The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro. Brain Research 1159 (1) : 8-17. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2007.04.066
Abstract: Opposing functions of activated microglia, namely neuroprotection or neurotrophy versus neurodestruction or neurotoxicity, have been observed in a number of experimental models of neurotrauma and neurodegenerative diseases. However, the mechanism(s) involved in the determination of which function activated microglia execute under a given set of conditions still remains to be elucidated. Our current in vitro study has revealed that a neuroprotective/neurotrophic or a neurodestructive/neurotoxic microglial function may be configured by the equilibrium among various microglial factors released into the microenvironment. When NSC-34 neurons were treated with lower concentrations of lipopolysaccharide-stimulated BV-2 microglial conditioned medium (LPS-BVCM), viability of the NSC-34 neurons increased, outgrowth of neuronal processes was promoted, and the formation of 2,5-hexanedione-induced aggregates was prevented. However, when NSC-34 neurons were treated with higher concentrations of the same LPS-BVCM, neuronal viability was reduced, apoptosis was induced and outgrowth of neuronal processes was prevented. Measurement of the cytokines tumor necrotic factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 in the LPS-BVCM has shown that the upregulation in expression for each cytokine varied both temporally and quantitatively. It is postulated that an alteration in the concentration of the LPS-BVCM might significantly affect the functional balance of microglial factors in the microenvironment with a resultant different microglial function. © 2007 Elsevier B.V. All rights reserved.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/24316
ISSN: 00068993
DOI: 10.1016/j.brainres.2007.04.066
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