Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2007.04.066
DC FieldValue
dc.titleThe function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro
dc.contributor.authorLi, L.
dc.contributor.authorLu, J.
dc.contributor.authorTay, S.S.W.
dc.contributor.authorHe, B.P.
dc.contributor.authorMoochhala, S.M.
dc.date.accessioned2011-07-25T02:42:46Z
dc.date.available2011-07-25T02:42:46Z
dc.date.issued2007
dc.identifier.citationLi, L., Lu, J., Tay, S.S.W., He, B.P., Moochhala, S.M. (2007). The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro. Brain Research 1159 (1) : 8-17. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2007.04.066
dc.identifier.issn00068993
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/24316
dc.description.abstractOpposing functions of activated microglia, namely neuroprotection or neurotrophy versus neurodestruction or neurotoxicity, have been observed in a number of experimental models of neurotrauma and neurodegenerative diseases. However, the mechanism(s) involved in the determination of which function activated microglia execute under a given set of conditions still remains to be elucidated. Our current in vitro study has revealed that a neuroprotective/neurotrophic or a neurodestructive/neurotoxic microglial function may be configured by the equilibrium among various microglial factors released into the microenvironment. When NSC-34 neurons were treated with lower concentrations of lipopolysaccharide-stimulated BV-2 microglial conditioned medium (LPS-BVCM), viability of the NSC-34 neurons increased, outgrowth of neuronal processes was promoted, and the formation of 2,5-hexanedione-induced aggregates was prevented. However, when NSC-34 neurons were treated with higher concentrations of the same LPS-BVCM, neuronal viability was reduced, apoptosis was induced and outgrowth of neuronal processes was prevented. Measurement of the cytokines tumor necrotic factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 in the LPS-BVCM has shown that the upregulation in expression for each cytokine varied both temporally and quantitatively. It is postulated that an alteration in the concentration of the LPS-BVCM might significantly affect the functional balance of microglial factors in the microenvironment with a resultant different microglial function. © 2007 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.brainres.2007.04.066
dc.sourceScopus
dc.subject2,5-Hexanedione
dc.subjectDual function
dc.subjectMicroglia
dc.subjectNeurodegeneration
dc.subjectNeuroprotection
dc.subjectNeurotoxicity
dc.typeArticle
dc.contributor.departmentANATOMY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.brainres.2007.04.066
dc.description.sourcetitleBrain Research
dc.description.volume1159
dc.description.issue1
dc.description.page8-17
dc.identifier.isiut000248614100002
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