Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms24043928
Title: Impact of Microplastics on the Ocular Surface
Authors: Wu, Duoduo
Lim, Blanche XH
Seah, Ivan 
Xie, Shay
Jaeger, Julia E
Symons, Robert K
Heffernan, Amy L
Curren, Emily EM
Leong, Sandric CY 
Riau, Andri K 
Lim, Dawn KA 
Stapleton, Fiona
Ali, Mohammad Javed
Singh, Swati
Tong, Louis 
Mehta, Jodhbir S 
Su, Xinyi 
Lim, Chris HL
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
microplastics
ocular surface
dry eye disease
polymers
dysbiosis
oxidative stress
inflammation
ATOMIC-FORCE MICROSCOPY
SOFT CONTACT-LENS
MICROBIOTA DYSBIOSIS
PHTHALATE EXPOSURE
SPECTRAL LIBRARIES
OXIDATIVE STRESS
IDENTIFICATION
SPECTROSCOPY
FTIR
GUT
Issue Date: 1-Feb-2023
Publisher: MDPI
Citation: Wu, Duoduo, Lim, Blanche XH, Seah, Ivan, Xie, Shay, Jaeger, Julia E, Symons, Robert K, Heffernan, Amy L, Curren, Emily EM, Leong, Sandric CY, Riau, Andri K, Lim, Dawn KA, Stapleton, Fiona, Ali, Mohammad Javed, Singh, Swati, Tong, Louis, Mehta, Jodhbir S, Su, Xinyi, Lim, Chris HL (2023-02-01). Impact of Microplastics on the Ocular Surface. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 (4). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms24043928
Abstract: Plastics are synthetic materials made from organic polymers that are ubiquitous in daily living and are especially important in the healthcare setting. However, recent advances have revealed the pervasive nature of microplastics, which are formed by degradation of existing plastic products. Although the impact on human health has yet to be fully characterised, there is increasing evidence that microplastics can trigger inflammatory damage, microbial dysbiosis, and oxidative stress in humans. Although there are limited studies investigating their effect on the ocular surface, studies of microplastics on other organs provide some insights. The prevalence of plastic waste has also triggered public outcry, culminating in the development of legislation aimed at reducing microplastics in commercial products. We present a review outlining the possible sources of microplastics leading to ocular exposure, and analyse the possible mechanisms of ocular surface damage. Finally, we examine the utility and consequences of current legislation surrounding microplastic regulation.
Source Title: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/242011
ISSN: 1661-6596,1422-0067
DOI: 10.3390/ijms24043928
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