Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.gpb.2017.07.002
Title: OrthoGNC: A Software for Accurate Identification of Orthologs Based on Gene Neighborhood Conservation
Authors: Jahangiri-Tazehkand, Soheil
Wong, Limsoon 
Eslahchi, Changiz
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Orthology
Homology
Gene neighborhood conservation
Genomic context
Comparative genomics
PHYLOGENETIC TREES
EVOLUTIONARY
BACTERIAL
PARALOGS
DATABASE
SEARCH
QUEST
PLANT
VIEW
Issue Date: Dec-2017
Publisher: ELSEVIER
Citation: Jahangiri-Tazehkand, Soheil, Wong, Limsoon, Eslahchi, Changiz (2017-12). OrthoGNC: A Software for Accurate Identification of Orthologs Based on Gene Neighborhood Conservation. GENOMICS PROTEOMICS & BIOINFORMATICS 15 (6) : 361-370. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gpb.2017.07.002
Abstract: Orthology relations can be used to transfer annotations from one gene (or protein) to another. Hence, detecting orthology relations has become an important task in the post-genomic era. Various genomic events, such as duplication and horizontal gene transfer, can cause erroneous assignment of orthology relations. In closely-related species, gene neighborhood information can be used to resolve many ambiguities in orthology inference. Here we present OrthoGNC, a software for accurately predicting pairwise orthology relations based on gene neighborhood conservation. Analyses on simulated and real data reveal the high accuracy of OrthoGNC. In addition to orthology detection, OrthoGNC can be employed to investigate the conservation of genomic context among potential orthologs detected by other methods. OrthoGNC is freely available online at http://bs.ipm.ir/softwares/orthognc and http://tinyurl.com/orthoGNC.
Source Title: GENOMICS PROTEOMICS & BIOINFORMATICS
URI: https://scholarbank.nus.edu.sg/handle/10635/241872
ISSN: 1672-0229
2210-3244
DOI: 10.1016/j.gpb.2017.07.002
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