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https://doi.org/10.3389/fcell.2022.1038107
Title: | Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis | Authors: | Biswas, Arikta Ng, Boon Heng Prabhakaran, Vinod SO Chan, Chii Jou |
Keywords: | folliculogenesis mechanobiology oocyte mechanotransduction mammalian reproduction theca cell |
Issue Date: | 2-Dec-2022 | Publisher: | FRONTIERS MEDIA SA | Citation: | Biswas, Arikta, Ng, Boon Heng, Prabhakaran, Vinod SO, Chan, Chii Jou (2022-12-02). Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10. ScholarBank@NUS Repository. https://doi.org/10.3389/fcell.2022.1038107 | Abstract: | The formation of functional eggs (oocyte) in ovarian follicles is arguably one of the most important events in early mammalian development since the oocytes provide the bulk genetic and cytoplasmic materials for successful reproduction. While past studies have identified many genes that are critical to normal ovarian development and function, recent studies have highlighted the role of mechanical force in shaping folliculogenesis. In this review, we discuss the underlying mechanobiological principles and the force-generating cellular structures and extracellular matrix that control the various stages of follicle development. We also highlight emerging techniques that allow for the quantification of mechanical interactions and follicular dynamics during development, and propose new directions for future studies in the field. We hope this review will provide a timely and useful framework for future understanding of mechano-signalling pathways in reproductive biology and diseases. | Source Title: | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | URI: | https://scholarbank.nus.edu.sg/handle/10635/241871 | ISSN: | 2296-634X | DOI: | 10.3389/fcell.2022.1038107 |
Appears in Collections: | Staff Publications Elements Students Publications |
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