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https://doi.org/10.1016/j.neuint.2021.105251
Title: | Elevation of inactive cleaved annexin A1 in the neocortex is associated with amyloid, inflammatory and apoptotic markers in neurodegenerative dementias | Authors: | Chua, Xin Ying Chong, Joyce R Lee, Jasinda H Ballard, Clive Aarsland, Dag Francis, Paul T Cheng, Ai Ling Lai, Mitchell KP |
Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Neurosciences Neurosciences & Neurology Annexin A1 Alzheimer's disease Apoptosis Dementia with lewy bodies Neuroinflammation Parkinson's disease dementia ALZHEIMERS-DISEASE LEWY BODIES NEUROPATHOLOGIC ASSESSMENT RESOLUTION BRAIN NEUROINFLAMMATION NEUROTOXICITY MECHANISMS A-BETA(42) DIAGNOSIS |
Issue Date: | 1-Jan-2022 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Citation: | Chua, Xin Ying, Chong, Joyce R, Lee, Jasinda H, Ballard, Clive, Aarsland, Dag, Francis, Paul T, Cheng, Ai Ling, Lai, Mitchell KP (2022-01-01). Elevation of inactive cleaved annexin A1 in the neocortex is associated with amyloid, inflammatory and apoptotic markers in neurodegenerative dementias. NEUROCHEMISTRY INTERNATIONAL 152. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuint.2021.105251 | Abstract: | Inflammation is usually a tightly regulated process whose termination by mediators including Annexin A1 (AnxA1) results in the resolution of inflammatory responses. In neurodegenerative dementias, chronic neuroinflammation, along with accumulation of aggregated β-amyloid (Aβ) peptides and apoptosis, has long been recognized to be a pathological hallmark; but it is unclear whether a failure of inflammation resolution contributes to this pathophysiological process. In this study, we measured AnxA1 immunoreactivities in postmortem neocortex (Brodmann areas BA9 and BA40) of well characterized Alzheimer's disease (AD), Parkinson disease dementia (PDD) and dementia with Lewy bodies (DLB) patients as well as aged controls. Inactive cleaved AnxA1 was found to be elevated in AD and DLB in BA40. Levels of cleaved AnxA1 also positively correlated with amyloidogenic brain Aβ, anti-inflammatory markers such as IL10 and IL13, as well as with the pro-apoptotic marker cleaved caspase-3 in BA40. Our findings suggest that elevated cleaved AnxA1 in neurodegenerative dementias may reflect a failure of inflammation resolution in certain regions of the diseased brain, and also support a mechanistic link between AnxA1 and amyloid pathology, neuroinflammation and apoptosis. | Source Title: | NEUROCHEMISTRY INTERNATIONAL | URI: | https://scholarbank.nus.edu.sg/handle/10635/241007 | ISSN: | 0197-0186 1872-9754 |
DOI: | 10.1016/j.neuint.2021.105251 |
Appears in Collections: | Staff Publications Elements |
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