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|Human Milk Antibodies Elicited by BNT162b2 Vaccination have reduced activity against SARS-CoV-2 Variants of Concern
|Low, Jia Ming
Ng, Melissa Shu Feng
Wang, Liang Wei
|Low, Jia Ming, Gu, Yue, Ng, Melissa Shu Feng, Wang, Liang Wei, Amin, Zubair, Zhong, Youjia, MacAry, Paul (2021). Human Milk Antibodies Elicited by BNT162b2 Vaccination have reduced activity against SARS-CoV-2 Variants of Concern. ScholarBank@NUS Repository. https://doi.org/10.1101/2021.09.20.21263808
|We detected the presence of SARS-CoV-2 specific IgA against all major VOCs in milk out to 6 weeks after D2 of BNT162b2. These likely confer some protection to the breastfed infants, who are ineligible for vaccination and are at risk of severe COVID-19. However, we detected significantly reduced milk IgA binding to VOCs, including the globally dominant Delta variant, suggesting reduced protection for breastfeeding infants. Additionally, these antibodies were significantly reduced by as early as 4-6 weeks after D2.
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