Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.isci.2022.105194
Title: | Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer | Authors: | Myint, Khine Chuang, Linda Shyue Huey Teh, Yu Xuan Mawan, Nur Astiana Shi, Edward Jizhong Mok, Michelle Meng Huang Nuttonmanit, Napat Matsuo, Junichi Li, Ying Yang, Henry Okabe, Atsushi Kaneda, Atsushi Osato, Motomi So, Jimmy Bok-Yan Yong, Wei Peng Tan, Patrick Yeoh, Khay Guan Ito, Yoshiaki |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics TRANSCRIPTION FACTOR FOXM1 SERUM RESPONSE FACTOR HEPATOCELLULAR-CARCINOMA UP-REGULATION RNA PROLIFERATION OVEREXPRESSION PROMOTES ACTIN CYTOSKELETON |
Issue Date: | 21-Oct-2022 | Publisher: | CELL PRESS | Citation: | Myint, Khine, Chuang, Linda Shyue Huey, Teh, Yu Xuan, Mawan, Nur Astiana, Shi, Edward Jizhong, Mok, Michelle Meng Huang, Nuttonmanit, Napat, Matsuo, Junichi, Li, Ying, Yang, Henry, Okabe, Atsushi, Kaneda, Atsushi, Osato, Motomi, So, Jimmy Bok-Yan, Yong, Wei Peng, Tan, Patrick, Yeoh, Khay Guan, Ito, Yoshiaki (2022-10-21). Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer. ISCIENCE 25 (10). ScholarBank@NUS Repository. https://doi.org/10.1016/j.isci.2022.105194 | Abstract: | We reported earlier that IQGAP3 is an important stem cell factor in rapidly proliferating isthmus stem cells in the stomach and that IQGAP3 expression is robustly induced in terminally differentiated chief cells and de-differentiated cells following tissue damage. The elevated IQGAP3 expression in cancer and its association with metastasis suggest a fundamental role for IQGAP3 in proliferating cancer stem cells. What causes IQGAP3 upregulation in cancer is unclear. Here, we show that IGF2BP1 and IQGAP3 expression levels are highest in the blastocyst, with both decreasing during adulthood. This suggests that IQGAP3, like IGF2BP1, is an early developmental gene that is aberrantly upregulated upon re-expression of IGF2BP1 during carcinogenesis. IGF2BP1 binds and stabilizes m6A-modified IQGAP3 transcripts. Downstream targets of IGF2BP1, namely SRF and FOXM1, also upregulate IQGAP3 expression. These multiple layers of IQGAP3 regulation, which may safeguard against inappropriate stem cell proliferation, present additional drug targets to inhibit IQGAP3-driven malignant growth. | Source Title: | ISCIENCE | URI: | https://scholarbank.nus.edu.sg/handle/10635/239100 | ISSN: | 2589-0042 | DOI: | 10.1016/j.isci.2022.105194 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer.pdf | Published version | 3.29 MB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.