Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.isci.2022.105194
Title: Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer
Authors: Myint, Khine 
Chuang, Linda Shyue Huey 
Teh, Yu Xuan 
Mawan, Nur Astiana 
Shi, Edward Jizhong
Mok, Michelle Meng Huang 
Nuttonmanit, Napat 
Matsuo, Junichi 
Li, Ying 
Yang, Henry
Okabe, Atsushi
Kaneda, Atsushi
Osato, Motomi 
So, Jimmy Bok-Yan 
Yong, Wei Peng 
Tan, Patrick 
Yeoh, Khay Guan 
Ito, Yoshiaki 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
TRANSCRIPTION FACTOR FOXM1
SERUM RESPONSE FACTOR
HEPATOCELLULAR-CARCINOMA
UP-REGULATION
RNA
PROLIFERATION
OVEREXPRESSION
PROMOTES
ACTIN
CYTOSKELETON
Issue Date: 21-Oct-2022
Publisher: CELL PRESS
Citation: Myint, Khine, Chuang, Linda Shyue Huey, Teh, Yu Xuan, Mawan, Nur Astiana, Shi, Edward Jizhong, Mok, Michelle Meng Huang, Nuttonmanit, Napat, Matsuo, Junichi, Li, Ying, Yang, Henry, Okabe, Atsushi, Kaneda, Atsushi, Osato, Motomi, So, Jimmy Bok-Yan, Yong, Wei Peng, Tan, Patrick, Yeoh, Khay Guan, Ito, Yoshiaki (2022-10-21). Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer. ISCIENCE 25 (10). ScholarBank@NUS Repository. https://doi.org/10.1016/j.isci.2022.105194
Abstract: We reported earlier that IQGAP3 is an important stem cell factor in rapidly proliferating isthmus stem cells in the stomach and that IQGAP3 expression is robustly induced in terminally differentiated chief cells and de-differentiated cells following tissue damage. The elevated IQGAP3 expression in cancer and its association with metastasis suggest a fundamental role for IQGAP3 in proliferating cancer stem cells. What causes IQGAP3 upregulation in cancer is unclear. Here, we show that IGF2BP1 and IQGAP3 expression levels are highest in the blastocyst, with both decreasing during adulthood. This suggests that IQGAP3, like IGF2BP1, is an early developmental gene that is aberrantly upregulated upon re-expression of IGF2BP1 during carcinogenesis. IGF2BP1 binds and stabilizes m6A-modified IQGAP3 transcripts. Downstream targets of IGF2BP1, namely SRF and FOXM1, also upregulate IQGAP3 expression. These multiple layers of IQGAP3 regulation, which may safeguard against inappropriate stem cell proliferation, present additional drug targets to inhibit IQGAP3-driven malignant growth.
Source Title: ISCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/239100
ISSN: 2589-0042
DOI: 10.1016/j.isci.2022.105194
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