Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.diabres.2013.11.013
Title: Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients
Authors: Asanghanwa, Milca
Gorus, Frans K
Weets, Ilse
Auwera, Bart V der
Aminkeng, Folefac 
Mbunwe, Eric
Goubert, Patrick
Verhaeghen, Katrijn
Sobngwi, Eugene
Wenzlau, Janet M
Hutton, John C
Pipeleers, Daniel G
Keymeulen, Bart
Mbanya, Jean-Claude N
van Schravendijk, Chris
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Autoantibodies
Classification
Diabetes
Sub-Saharan Africa
ISLET CELL ANTIBODIES
C-PEPTIDE
IDDM PATIENTS
TYPE-1
CLASSIFICATION
FREQUENCY
DISEASE
ADULTS
AUTOIMMUNITY
PATHOGENESIS
Issue Date: 1-Jan-2014
Publisher: ELSEVIER IRELAND LTD
Citation: Asanghanwa, Milca, Gorus, Frans K, Weets, Ilse, Auwera, Bart V der, Aminkeng, Folefac, Mbunwe, Eric, Goubert, Patrick, Verhaeghen, Katrijn, Sobngwi, Eugene, Wenzlau, Janet M, Hutton, John C, Pipeleers, Daniel G, Keymeulen, Bart, Mbanya, Jean-Claude N, van Schravendijk, Chris (2014-01-01). Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients. DIABETES RESEARCH AND CLINICAL PRACTICE 103 (1) : 97-105. ScholarBank@NUS Repository. https://doi.org/10.1016/j.diabres.2013.11.013
Abstract: Aims: We investigated the prevalence of diabetes autoantibodies (Abs) in Cameroonian patients and controls, assessed their contribution in disease classification and compared results with data from Belgium. Methods: Abs against GAD (GADA), IA-2 (IA-2A) and zinc transporter 8 (ZnT8A) were assessed in 302 recently diagnosed Cameroonian patients with diabetes and 184 control subjects without diabetes aged below 40 years. Results: Only 27 (9%) Cameroonian patients were younger than 15 years. Overall, 29% of patients presented at least one diabetes-associated antibody vs 9% in healthy controls (24% vs 7% for GADA (p<0.001), 10% vs 3% for IA-2A (p<0.006), 4% vs 2% for ZnT8A). Ab+ patients had lower C-peptide levels (p<0.001), were more often insulin-treated (p<0.002) and were as frequently diagnosed with type 1 diabetes as Ab- patients. Only 43% of Ab+ patients aged 15-39 years were clinically classified as having type 1 diabetes in Cameroon vs 96% in Belgium (p<0.001). Not one Ab+ Cameroonian patient carried HLA-DQ2/DQ8 genotype vs 23% of Belgian Ab+ patients (p<0.001). Younger age at diagnosis and antibody positivity were independent predictors of insulin therapy. Ab+ Cameroonian patients were older (p<0.001), had higher BMI (p<0.001) and lower Ab titers than Belgian Ab+ patients. In ketonuric patients, prevalence of autoantibodies was similar as in non-ketonuric patients. Conclusions: In Cameroonian patients with diabetes aged under 40 years, antibody-positivity is not clearly related to disease phenotype, but may help predict the need for insulin treatment. © 2013 Elsevier Ireland Ltd.
Source Title: DIABETES RESEARCH AND CLINICAL PRACTICE
URI: https://scholarbank.nus.edu.sg/handle/10635/235307
ISSN: 0168-8227
1872-8227
DOI: 10.1016/j.diabres.2013.11.013
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