Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.diabres.2013.11.013
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dc.titleClinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients
dc.contributor.authorAsanghanwa, Milca
dc.contributor.authorGorus, Frans K
dc.contributor.authorWeets, Ilse
dc.contributor.authorAuwera, Bart V der
dc.contributor.authorAminkeng, Folefac
dc.contributor.authorMbunwe, Eric
dc.contributor.authorGoubert, Patrick
dc.contributor.authorVerhaeghen, Katrijn
dc.contributor.authorSobngwi, Eugene
dc.contributor.authorWenzlau, Janet M
dc.contributor.authorHutton, John C
dc.contributor.authorPipeleers, Daniel G
dc.contributor.authorKeymeulen, Bart
dc.contributor.authorMbanya, Jean-Claude N
dc.contributor.authorvan Schravendijk, Chris
dc.date.accessioned2022-12-05T02:48:29Z
dc.date.available2022-12-05T02:48:29Z
dc.date.issued2014-01-01
dc.identifier.citationAsanghanwa, Milca, Gorus, Frans K, Weets, Ilse, Auwera, Bart V der, Aminkeng, Folefac, Mbunwe, Eric, Goubert, Patrick, Verhaeghen, Katrijn, Sobngwi, Eugene, Wenzlau, Janet M, Hutton, John C, Pipeleers, Daniel G, Keymeulen, Bart, Mbanya, Jean-Claude N, van Schravendijk, Chris (2014-01-01). Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients. DIABETES RESEARCH AND CLINICAL PRACTICE 103 (1) : 97-105. ScholarBank@NUS Repository. https://doi.org/10.1016/j.diabres.2013.11.013
dc.identifier.issn0168-8227
dc.identifier.issn1872-8227
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/235307
dc.description.abstractAims: We investigated the prevalence of diabetes autoantibodies (Abs) in Cameroonian patients and controls, assessed their contribution in disease classification and compared results with data from Belgium. Methods: Abs against GAD (GADA), IA-2 (IA-2A) and zinc transporter 8 (ZnT8A) were assessed in 302 recently diagnosed Cameroonian patients with diabetes and 184 control subjects without diabetes aged below 40 years. Results: Only 27 (9%) Cameroonian patients were younger than 15 years. Overall, 29% of patients presented at least one diabetes-associated antibody vs 9% in healthy controls (24% vs 7% for GADA (p<0.001), 10% vs 3% for IA-2A (p<0.006), 4% vs 2% for ZnT8A). Ab+ patients had lower C-peptide levels (p<0.001), were more often insulin-treated (p<0.002) and were as frequently diagnosed with type 1 diabetes as Ab- patients. Only 43% of Ab+ patients aged 15-39 years were clinically classified as having type 1 diabetes in Cameroon vs 96% in Belgium (p<0.001). Not one Ab+ Cameroonian patient carried HLA-DQ2/DQ8 genotype vs 23% of Belgian Ab+ patients (p<0.001). Younger age at diagnosis and antibody positivity were independent predictors of insulin therapy. Ab+ Cameroonian patients were older (p<0.001), had higher BMI (p<0.001) and lower Ab titers than Belgian Ab+ patients. In ketonuric patients, prevalence of autoantibodies was similar as in non-ketonuric patients. Conclusions: In Cameroonian patients with diabetes aged under 40 years, antibody-positivity is not clearly related to disease phenotype, but may help predict the need for insulin treatment. © 2013 Elsevier Ireland Ltd.
dc.language.isoen
dc.publisherELSEVIER IRELAND LTD
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectEndocrinology & Metabolism
dc.subjectAutoantibodies
dc.subjectClassification
dc.subjectDiabetes
dc.subjectSub-Saharan Africa
dc.subjectISLET CELL ANTIBODIES
dc.subjectC-PEPTIDE
dc.subjectIDDM PATIENTS
dc.subjectTYPE-1
dc.subjectCLASSIFICATION
dc.subjectFREQUENCY
dc.subjectDISEASE
dc.subjectADULTS
dc.subjectAUTOIMMUNITY
dc.subjectPATHOGENESIS
dc.typeArticle
dc.date.updated2022-11-30T19:04:12Z
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.diabres.2013.11.013
dc.description.sourcetitleDIABETES RESEARCH AND CLINICAL PRACTICE
dc.description.volume103
dc.description.issue1
dc.description.page97-105
dc.published.statePublished
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