Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.diabres.2013.11.013
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dc.title | Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients | |
dc.contributor.author | Asanghanwa, Milca | |
dc.contributor.author | Gorus, Frans K | |
dc.contributor.author | Weets, Ilse | |
dc.contributor.author | Auwera, Bart V der | |
dc.contributor.author | Aminkeng, Folefac | |
dc.contributor.author | Mbunwe, Eric | |
dc.contributor.author | Goubert, Patrick | |
dc.contributor.author | Verhaeghen, Katrijn | |
dc.contributor.author | Sobngwi, Eugene | |
dc.contributor.author | Wenzlau, Janet M | |
dc.contributor.author | Hutton, John C | |
dc.contributor.author | Pipeleers, Daniel G | |
dc.contributor.author | Keymeulen, Bart | |
dc.contributor.author | Mbanya, Jean-Claude N | |
dc.contributor.author | van Schravendijk, Chris | |
dc.date.accessioned | 2022-12-05T02:48:29Z | |
dc.date.available | 2022-12-05T02:48:29Z | |
dc.date.issued | 2014-01-01 | |
dc.identifier.citation | Asanghanwa, Milca, Gorus, Frans K, Weets, Ilse, Auwera, Bart V der, Aminkeng, Folefac, Mbunwe, Eric, Goubert, Patrick, Verhaeghen, Katrijn, Sobngwi, Eugene, Wenzlau, Janet M, Hutton, John C, Pipeleers, Daniel G, Keymeulen, Bart, Mbanya, Jean-Claude N, van Schravendijk, Chris (2014-01-01). Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients. DIABETES RESEARCH AND CLINICAL PRACTICE 103 (1) : 97-105. ScholarBank@NUS Repository. https://doi.org/10.1016/j.diabres.2013.11.013 | |
dc.identifier.issn | 0168-8227 | |
dc.identifier.issn | 1872-8227 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/235307 | |
dc.description.abstract | Aims: We investigated the prevalence of diabetes autoantibodies (Abs) in Cameroonian patients and controls, assessed their contribution in disease classification and compared results with data from Belgium. Methods: Abs against GAD (GADA), IA-2 (IA-2A) and zinc transporter 8 (ZnT8A) were assessed in 302 recently diagnosed Cameroonian patients with diabetes and 184 control subjects without diabetes aged below 40 years. Results: Only 27 (9%) Cameroonian patients were younger than 15 years. Overall, 29% of patients presented at least one diabetes-associated antibody vs 9% in healthy controls (24% vs 7% for GADA (p<0.001), 10% vs 3% for IA-2A (p<0.006), 4% vs 2% for ZnT8A). Ab+ patients had lower C-peptide levels (p<0.001), were more often insulin-treated (p<0.002) and were as frequently diagnosed with type 1 diabetes as Ab- patients. Only 43% of Ab+ patients aged 15-39 years were clinically classified as having type 1 diabetes in Cameroon vs 96% in Belgium (p<0.001). Not one Ab+ Cameroonian patient carried HLA-DQ2/DQ8 genotype vs 23% of Belgian Ab+ patients (p<0.001). Younger age at diagnosis and antibody positivity were independent predictors of insulin therapy. Ab+ Cameroonian patients were older (p<0.001), had higher BMI (p<0.001) and lower Ab titers than Belgian Ab+ patients. In ketonuric patients, prevalence of autoantibodies was similar as in non-ketonuric patients. Conclusions: In Cameroonian patients with diabetes aged under 40 years, antibody-positivity is not clearly related to disease phenotype, but may help predict the need for insulin treatment. © 2013 Elsevier Ireland Ltd. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER IRELAND LTD | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Endocrinology & Metabolism | |
dc.subject | Autoantibodies | |
dc.subject | Classification | |
dc.subject | Diabetes | |
dc.subject | Sub-Saharan Africa | |
dc.subject | ISLET CELL ANTIBODIES | |
dc.subject | C-PEPTIDE | |
dc.subject | IDDM PATIENTS | |
dc.subject | TYPE-1 | |
dc.subject | CLASSIFICATION | |
dc.subject | FREQUENCY | |
dc.subject | DISEASE | |
dc.subject | ADULTS | |
dc.subject | AUTOIMMUNITY | |
dc.subject | PATHOGENESIS | |
dc.type | Article | |
dc.date.updated | 2022-11-30T19:04:12Z | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1016/j.diabres.2013.11.013 | |
dc.description.sourcetitle | DIABETES RESEARCH AND CLINICAL PRACTICE | |
dc.description.volume | 103 | |
dc.description.issue | 1 | |
dc.description.page | 97-105 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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