Please use this identifier to cite or link to this item: https://doi.org/10.1053/j.semtcvs.2020.11.024
Title: Effect of Renin-Angiotensin System Inhibitors on Acute Kidney Injury Among Patients Undergoing Cardiac Surgery: A Review and Meta-Analysis
Authors: Zhou, Han
Xie, Jingui
Zheng, Zhichao
Ooi, Oon Cheong 
Luo, Haidong
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Acute kidney injury
Cardiac surgery
Renin-angiotensin system inhibitors
Angiotensin-converting enzyme inhibitors
Angiotensin II receptor blockers
CONVERTING ENZYME-INHIBITORS
BYPASS GRAFT-SURGERY
INTRAVENOUS ENALAPRILAT
CARDIOPULMONARY BYPASS
ATRIAL-FIBRILLATION
RECEPTOR BLOCKADE
RENAL-FUNCTION
THERAPY
OUTCOMES
RISK
Issue Date: 1-Jan-2021
Publisher: ELSEVIER INC
Citation: Zhou, Han, Xie, Jingui, Zheng, Zhichao, Ooi, Oon Cheong, Luo, Haidong (2021-01-01). Effect of Renin-Angiotensin System Inhibitors on Acute Kidney Injury Among Patients Undergoing Cardiac Surgery: A Review and Meta-Analysis. SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY 33 (4) : 1014-1022. ScholarBank@NUS Repository. https://doi.org/10.1053/j.semtcvs.2020.11.024
Abstract: Acute kidney injury (AKI) is a frequent complication of cardiac surgery, which can lead to higher mortality and long-term renal function impairment. The effect of perioperative renin-angiotensin system inhibitors (RASi) therapy on AKI incidence in patients undergoing cardiac surgery remains controversial. We reviewed related studies in PubMed, Scopus, and Cochrane Library from inception to February 2020. Two randomized controlled trials and 21 cohort studies were included in the meta-analysis, involving 76,321 participants. The pooled odds ratio and 95% confidence interval were calculated using the DerSimonian and Laird random-effects model. The results showed no significant association between perioperative RASi therapy and postoperative AKI in patients undergoing cardiac surgery. We highlighted the limitations of existing studies and called for well-designed large-scale randomized controlled trials to verify the conclusion.
Source Title: SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
URI: https://scholarbank.nus.edu.sg/handle/10635/235030
ISSN: 1043-0679
1532-9488
DOI: 10.1053/j.semtcvs.2020.11.024
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