Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12877-019-1253-5
Title: Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study
Authors: van Atteveld, Vera A
Van Ancum, Jeanine M
Reijnierse, Esmee M
Trappenburg, Marijke C
Meskers, Carel GM
Maier, Andrea B 
Keywords: Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Gerontology
Blood sedimentation
Albumin
White blood cells
Inflammation
Muscular atrophy
Outpatients
Sarcopenia
MUSCLE MASS
SKELETAL-MUSCLE
SERUM-ALBUMIN
OLDER MEN
STRENGTH
INTERLEUKIN-6
PREVALENCE
OBESITY
HEALTH
WOMEN
Issue Date: 27-Aug-2019
Publisher: BMC
Citation: van Atteveld, Vera A, Van Ancum, Jeanine M, Reijnierse, Esmee M, Trappenburg, Marijke C, Meskers, Carel GM, Maier, Andrea B (2019-08-27). Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study. BMC GERIATRICS 19 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12877-019-1253-5
Abstract: Background: Chronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia. We aimed to associate three markers of inflammation, erythrocyte sedimentation rate, albumin and white blood cell count, with measures of sarcopenia in geriatric outpatients. Methods: Data from the Centre Of Geriatrics Amsterdam cohort was used. Geriatric outpatients at the VU university medical centre in Amsterdam were recruited based on referral between January 1st 2014 and the 31st of December 2015. Erythrocyte sedimentation rate, albumin and white blood cell count were assessed from venous blood samples. Measures of sarcopenia included physical performance by measuring gait speed with the 4 meter walk test, duration of the timed up and go test and of the chair stand test, muscle strength by assessing handgrip strength using handheld dynamometry and skeletal muscle mass by performing bioelectrical impedance analysis. Multivariable linear regression analyses were performed to assess the associations between erythrocyte sedimentation rate, albumin, white blood cell count and measures of sarcopenia. Results: A total of 442 patients (mean age 80.8 years, SD 6.7, 58.1% female) were included. A higher erythrocyte sedimentation rate was significantly associated with lower gait speed (β = - 0.005; 95% CI = - 0.007, - 0.003), longer duration of timed up and go test (Ln β = 0.006; 95% CI = 0.003, 0.010), longer duration of chair stand test (Ln β = 0.005; 95% CI = 0.002, 0.008), lower handgrip strength (β = - 0.126; 95% CI = - 0.189, - 0.063) and lower relative skeletal muscle mass (β = - 0.179; 95% CI = - 0.274, - 0.084). Lower albumin levels were significantly associated with lower gait speed (β = - 0.020; 95% CI = - 0.011, - 0.028) and handgrip strength (β = - 0.596; 95% CI = - 0.311, - 0.881). Associations remained significant after adjustment for age, sex and number of morbidities. No significant associations were found for white blood cell count and measures of sarcopenia. Conclusions: In geriatric outpatients, erythrocyte sedimentation rate was associated with all three measures of sarcopenia, underpinning the potential role of inflammation in sarcopenia.
Source Title: BMC GERIATRICS
URI: https://scholarbank.nus.edu.sg/handle/10635/234963
ISSN: 1471-2318
DOI: 10.1186/s12877-019-1253-5
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