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https://doi.org/10.1186/s12877-018-0984-z
Title: | Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+study | Authors: | Legdeur, Nienke Badissi, Maryam Carter, Stephen F de Crom, Sophie van de Kreeke, Aleid Vreeswijk, Ralph Trappenburg, Marijke C Oudega, Mardien L Koek, Huiberdina L van Campen, Jos P Keijsers, Carolina JPW Amadi, Chinenye Hinz, Rainer Gordon, Mark F Novak, Gerald Podhorna, Jana Serne, Erik Verbraak, Frank Yaqub, Maqsood Hillebrand, Arjan Griffa, Alessandra Pendleton, Neil Kramer, Sophia E Teunissen, Charlotte E Lammertsma, Adriaan Barkhof, Frederik van Berckel, Bart NM Scheltens, Philip Muller, Majon Maier, Andrea B Herholz, Karl Visser, Pieter Jelle |
Keywords: | Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Alzheimer's disease Dementia Cognitive impairment Amnestic mild cognitive impairment Resilience Oldest-old Amyloid Positron emission tomography Magnetoencephalography (MEG) CARDIOVASCULAR RISK-FACTORS HIGH-DENSITY-LIPOPROTEIN GENOME-WIDE ASSOCIATION REFERENCE TISSUE MODEL WHITE-MATTER LESIONS ALL-CAUSE MORTALITY C-REACTIVE PROTEIN ALZHEIMERS-DISEASE BLOOD-PRESSURE CHINESE NONAGENARIANS |
Issue Date: | 26-Nov-2018 | Publisher: | BMC | Citation: | Legdeur, Nienke, Badissi, Maryam, Carter, Stephen F, de Crom, Sophie, van de Kreeke, Aleid, Vreeswijk, Ralph, Trappenburg, Marijke C, Oudega, Mardien L, Koek, Huiberdina L, van Campen, Jos P, Keijsers, Carolina JPW, Amadi, Chinenye, Hinz, Rainer, Gordon, Mark F, Novak, Gerald, Podhorna, Jana, Serne, Erik, Verbraak, Frank, Yaqub, Maqsood, Hillebrand, Arjan, Griffa, Alessandra, Pendleton, Neil, Kramer, Sophia E, Teunissen, Charlotte E, Lammertsma, Adriaan, Barkhof, Frederik, van Berckel, Bart NM, Scheltens, Philip, Muller, Majon, Maier, Andrea B, Herholz, Karl, Visser, Pieter Jelle (2018-11-26). Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+study. BMC GERIATRICS 18 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12877-018-0984-z | Abstract: | Background: The oldest-old (subjects aged 90 years and older) population represents the fastest growing segment of society and shows a high dementia prevalence rate of up to 40%. Only a few studies have investigated protective factors for cognitive impairment in the oldest-old. The EMIF-AD 90+ Study aims to identify factors associated with resilience to cognitive impairment in the oldest-old. In this paper we reviewed previous studies on cognitive resilience in the oldest-old and described the design of the EMIF-AD 90+ Study. Methods: The EMIF-AD 90+ Study aimed to enroll 80 cognitively normal subjects and 40 subjects with cognitive impairment aged 90 years or older. Cognitive impairment was operationalized as amnestic mild cognitive impairment (aMCI), or possible or probable Alzheimer's Disease (AD). The study was part of the European Medical Information Framework for AD (EMIF-AD) and was conducted at the Amsterdam University Medical Centers (UMC) and at the University of Manchester. We will test whether cognitive resilience is associated with cognitive reserve, vascular comorbidities, mood, sleep, sensory system capacity, physical performance and capacity, genetic risk factors, hallmarks of ageing, and markers of neurodegeneration. Markers of neurodegeneration included an amyloid positron emission tomography, amyloid β and tau in cerebrospinal fluid/blood and neurophysiological measures. Discussion: The EMIF-AD 90+ Study will extend our knowledge on resilience to cognitive impairment in the oldest-old by extensive phenotyping of the subjects and the measurement of a wide range of potential protective factors, hallmarks of aging and markers of neurodegeneration. Trial registration: Nederlands Trial Register NTR5867. Registered 20 May 2016. | Source Title: | BMC GERIATRICS | URI: | https://scholarbank.nus.edu.sg/handle/10635/234932 | ISSN: | 1471-2318 | DOI: | 10.1186/s12877-018-0984-z |
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