Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12877-018-0984-z
Title: Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+study
Authors: Legdeur, Nienke
Badissi, Maryam
Carter, Stephen F
de Crom, Sophie
van de Kreeke, Aleid
Vreeswijk, Ralph
Trappenburg, Marijke C
Oudega, Mardien L
Koek, Huiberdina L
van Campen, Jos P
Keijsers, Carolina JPW
Amadi, Chinenye
Hinz, Rainer
Gordon, Mark F
Novak, Gerald
Podhorna, Jana
Serne, Erik
Verbraak, Frank
Yaqub, Maqsood
Hillebrand, Arjan
Griffa, Alessandra
Pendleton, Neil
Kramer, Sophia E
Teunissen, Charlotte E
Lammertsma, Adriaan
Barkhof, Frederik
van Berckel, Bart NM
Scheltens, Philip
Muller, Majon
Maier, Andrea B 
Herholz, Karl
Visser, Pieter Jelle
Keywords: Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Gerontology
Alzheimer's disease
Dementia
Cognitive impairment
Amnestic mild cognitive impairment
Resilience
Oldest-old
Amyloid
Positron emission tomography
Magnetoencephalography (MEG)
CARDIOVASCULAR RISK-FACTORS
HIGH-DENSITY-LIPOPROTEIN
GENOME-WIDE ASSOCIATION
REFERENCE TISSUE MODEL
WHITE-MATTER LESIONS
ALL-CAUSE MORTALITY
C-REACTIVE PROTEIN
ALZHEIMERS-DISEASE
BLOOD-PRESSURE
CHINESE NONAGENARIANS
Issue Date: 26-Nov-2018
Publisher: BMC
Citation: Legdeur, Nienke, Badissi, Maryam, Carter, Stephen F, de Crom, Sophie, van de Kreeke, Aleid, Vreeswijk, Ralph, Trappenburg, Marijke C, Oudega, Mardien L, Koek, Huiberdina L, van Campen, Jos P, Keijsers, Carolina JPW, Amadi, Chinenye, Hinz, Rainer, Gordon, Mark F, Novak, Gerald, Podhorna, Jana, Serne, Erik, Verbraak, Frank, Yaqub, Maqsood, Hillebrand, Arjan, Griffa, Alessandra, Pendleton, Neil, Kramer, Sophia E, Teunissen, Charlotte E, Lammertsma, Adriaan, Barkhof, Frederik, van Berckel, Bart NM, Scheltens, Philip, Muller, Majon, Maier, Andrea B, Herholz, Karl, Visser, Pieter Jelle (2018-11-26). Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+study. BMC GERIATRICS 18 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12877-018-0984-z
Abstract: Background: The oldest-old (subjects aged 90 years and older) population represents the fastest growing segment of society and shows a high dementia prevalence rate of up to 40%. Only a few studies have investigated protective factors for cognitive impairment in the oldest-old. The EMIF-AD 90+ Study aims to identify factors associated with resilience to cognitive impairment in the oldest-old. In this paper we reviewed previous studies on cognitive resilience in the oldest-old and described the design of the EMIF-AD 90+ Study. Methods: The EMIF-AD 90+ Study aimed to enroll 80 cognitively normal subjects and 40 subjects with cognitive impairment aged 90 years or older. Cognitive impairment was operationalized as amnestic mild cognitive impairment (aMCI), or possible or probable Alzheimer's Disease (AD). The study was part of the European Medical Information Framework for AD (EMIF-AD) and was conducted at the Amsterdam University Medical Centers (UMC) and at the University of Manchester. We will test whether cognitive resilience is associated with cognitive reserve, vascular comorbidities, mood, sleep, sensory system capacity, physical performance and capacity, genetic risk factors, hallmarks of ageing, and markers of neurodegeneration. Markers of neurodegeneration included an amyloid positron emission tomography, amyloid β and tau in cerebrospinal fluid/blood and neurophysiological measures. Discussion: The EMIF-AD 90+ Study will extend our knowledge on resilience to cognitive impairment in the oldest-old by extensive phenotyping of the subjects and the measurement of a wide range of potential protective factors, hallmarks of aging and markers of neurodegeneration. Trial registration: Nederlands Trial Register NTR5867. Registered 20 May 2016.
Source Title: BMC GERIATRICS
URI: https://scholarbank.nus.edu.sg/handle/10635/234932
ISSN: 1471-2318
DOI: 10.1186/s12877-018-0984-z
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