Please use this identifier to cite or link to this item: https://doi.org/10.1093/gerona/glz180
Title: Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60-102 Years
Authors: Legdeur, Nienke
Tijms, Betty M
Konijnenberg, Elles
den Braber, Anouk
Ten Kate, Mara
Sudre, Carole H
Tomassen, Jori
Badissi, Maryam
Yaqub, Maqsood
Barkhof, Frederik
van Berckel, Bart N
Boomsma, Dorret
Scheltens, Philip
Holstege, Henne
Maier, Andrea B 
Visser, Pieter Jelle
Keywords: Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Gerontology
Biomarkers
Brain aging
Cognitive function
Human aging
ALZHEIMERS-DISEASE
TEMPORAL RELATIONSHIP
HANDGRIP STRENGTH
MUSCLE STRENGTH
APOE EPSILON-4
OLDER-ADULTS
SEX
DEMENTIA
PERFORMANCE
PREVALENCE
Issue Date: 1-Sep-2020
Publisher: OXFORD UNIV PRESS INC
Citation: Legdeur, Nienke, Tijms, Betty M, Konijnenberg, Elles, den Braber, Anouk, Ten Kate, Mara, Sudre, Carole H, Tomassen, Jori, Badissi, Maryam, Yaqub, Maqsood, Barkhof, Frederik, van Berckel, Bart N, Boomsma, Dorret, Scheltens, Philip, Holstege, Henne, Maier, Andrea B, Visser, Pieter Jelle (2020-09-01). Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60-102 Years. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 75 (9) : 1609-1617. ScholarBank@NUS Repository. https://doi.org/10.1093/gerona/glz180
Abstract: The prevalence of brain pathologies increases with age and cognitive and physical functions worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology cognitive and physical functions with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60- to 70-year-old individuals. Prevalence of abnormal scores was estimated using Generalized Estimating Equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test, and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass, and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education, and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology cognitive and physical processes became abnormal with age.
Source Title: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/234899
ISSN: 1079-5006
1758-535X
DOI: 10.1093/gerona/glz180
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60-102 Years.pdf963.86 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

3
checked on Feb 3, 2023

Page view(s)

14
checked on Feb 2, 2023

Download(s)

1
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.