Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mad.2020.111357
Title: The conundrum of human immune system "senescence"
Authors: Pawelec, Graham
Bronikowski, Anne
Cunnane, Stephen C
Ferrucci, Luigi
Franceschi, Claudio
Fulop, Tamas
Gaudreau, Pierrette
Gladyshev, Vadim N
Gonos, Efstathios S
Gorbunova, Vera
Kennedy, Brian K
Larbi, Anis 
Lemaitre, Jean-Francois
Liu, Guang-Hui
Maier, Andrea B 
Morais, Jose A
Nobrega, Otavio T
Moskalev, Alexey
Rikkert, Marcel Olde
Seluanov, Andrei
Senior, Alistair M
Ukraintseva, Svetlana
Vanhaelen, Quentin
Witkowski, Jacek
Cohen, Alan A
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Geriatrics & Gerontology
Human immunosenescence
Longitudinal study
Inflammageing
Cytomegalovirus
Vaccination
SWEDISH NONA IMMUNE
CD8(+) T-CELLS
CYTOMEGALOVIRUS-INFECTION
RISK PHENOTYPE
AGE
OLD
IMMUNOSENESCENCE
POPULATION
REPERTOIRE
STRATEGIES
Issue Date: 1-Dec-2020
Publisher: ELSEVIER IRELAND LTD
Citation: Pawelec, Graham, Bronikowski, Anne, Cunnane, Stephen C, Ferrucci, Luigi, Franceschi, Claudio, Fulop, Tamas, Gaudreau, Pierrette, Gladyshev, Vadim N, Gonos, Efstathios S, Gorbunova, Vera, Kennedy, Brian K, Larbi, Anis, Lemaitre, Jean-Francois, Liu, Guang-Hui, Maier, Andrea B, Morais, Jose A, Nobrega, Otavio T, Moskalev, Alexey, Rikkert, Marcel Olde, Seluanov, Andrei, Senior, Alistair M, Ukraintseva, Svetlana, Vanhaelen, Quentin, Witkowski, Jacek, Cohen, Alan A (2020-12-01). The conundrum of human immune system "senescence". MECHANISMS OF AGEING AND DEVELOPMENT 192. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mad.2020.111357
Abstract: There is a great deal of debate on the question of whether or not we know what ageing is (Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referred to as “immunosenescence”. But what exactly is meant by this term? It has been used loosely in the literature, resulting in a certain degree of confusion as to its definition and implications. Here, we argue that only those differences in immune parameters between younger and older adults that are associated in some definitive manner with detrimental health outcomes and/or impaired survival prospects should be classed as indicators of immunosenescence in the strictest sense of the word, and that in humans we know remarkably little about their identity. Such biomarkers of immunosenescence may nonetheless indicate beneficial effects in other contexts, consistent with the notion of antagonistic pleiotropy. Identifying what could be true immunosenescence in this respect requires examining: (1) what appears to correlate with age, though generality across human populations is not yet confirmed; (2) what clearly is part of a suite of canonical changes in the immune system that happen with age; (3) which subset of those changes accelerates rather than slows aging; and (4) all changes, potentially population-specific, that accelerate agig. This remains an immense challenge. These questions acquire an added urgency in the current SARS-CoV-2 pandemic, given the clearly greater susceptibility of older adults to COVID-19.
Source Title: MECHANISMS OF AGEING AND DEVELOPMENT
URI: https://scholarbank.nus.edu.sg/handle/10635/234892
ISSN: 0047-6374
1872-6216
DOI: 10.1016/j.mad.2020.111357
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

23
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.