Please use this identifier to cite or link to this item: https://doi.org/10.3389/fnagi.2022.930686
Title: Olfactory dysfunction is associated with mild cognitive impairment in community-dwelling older adults
Authors: Yap, Ai Che 
Mahendran, Rathi 
Kua, Ee Heok 
Zhou, Weibiao 
Wang, De Yun 
Keywords: olfaction
smell identification
cognition
amnestic
mild cognitive impairment
Issue Date: 8-Aug-2022
Publisher: FRONTIERS MEDIA SA
Citation: Yap, Ai Che, Mahendran, Rathi, Kua, Ee Heok, Zhou, Weibiao, Wang, De Yun (2022-08-08). Olfactory dysfunction is associated with mild cognitive impairment in community-dwelling older adults. FRONTIERS IN AGING NEUROSCIENCE 14. ScholarBank@NUS Repository. https://doi.org/10.3389/fnagi.2022.930686
Abstract: Background: Olfactory impairment is aging related and is associated with cognitive decline in older adults. However, it remains unclear if an olfactory impairment is associated with mild cognitive impairment (MCI) and the degree of impairment in the MCI subtypes. Materials and methods: In a cohort of community-living older adults aged 60 years and above, 670 participants were recruited from the Community Health and Intergenerational (CHI) Study. Olfactory function was assessed using a locally developed nine-item smell test in association with neurocognitive assessments. Analysis of covariance (ANCOVA) was used to examine the association of smell identification score and clinical cognitive status while considering demographic, clinical, and neuropsychological factors with Bonferroni correction for group comparisons. Results: Age-related smell detection between normal aging (NA) and MCI participants had no significant difference. The overall mean smell identification score in older adults was negatively correlated with age. The mean smell identification score of MCI participants was also not significantly different as compared with NA, but an amnestic MCI multiple domain (aMCI_MD) subgroup had significantly lower (impaired) mean smell identification scores compared with the NA and MCI single domain (amnestic and non-amnestic) group. Conclusion: This study demonstrated that olfactory identification impairment is a comorbidity in older adults with amnestic MCI (aMCI) and is a potential marker associated with an early stage of a neurocognitive disorder. The smell test could act as a screening tool to help in the early detection of smell impairment for heterogeneous syndromes of MCI among community-dwelling older adults. Clinicians and researchers could benefit from utilizing the locally developed smell test to screen their patients or research participants before the initiation of an appropriate health intervention or in a clinical trial.
Source Title: FRONTIERS IN AGING NEUROSCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/234158
ISSN: 1663-4365
DOI: 10.3389/fnagi.2022.930686
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