Please use this identifier to cite or link to this item: https://doi.org/10.26508/lsa.201900490
Title: The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
Authors: Zacarías-Fluck, M.F.
Jauset, Toni
Martínez-Martín, S.
Kaur, Jastrinjan
Casacuberta-Serra, Silvia
Massó-Vallés, D.
Serrano del Pozo, Erika
Martín-Fernández, G.
González-Larreategui, Í.
López-Estévez, S.
Brown-Swigart, Lamorna
Beaulieu, Marie-Eve
Whitfield, Jonathan R.
Madan, Babita 
Virshup, David M. 
Evan, Gerard, I
Soucek, Laura
Issue Date: 2-Mar-2021
Publisher: Rockefeller University Press
Citation: Zacarías-Fluck, M.F., Jauset, Toni, Martínez-Martín, S., Kaur, Jastrinjan, Casacuberta-Serra, Silvia, Massó-Vallés, D., Serrano del Pozo, Erika, Martín-Fernández, G., González-Larreategui, Í., López-Estévez, S., Brown-Swigart, Lamorna, Beaulieu, Marie-Eve, Whitfield, Jonathan R., Madan, Babita, Virshup, David M., Evan, Gerard, I, Soucek, Laura (2021-03-02). The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets. Life Science Alliance 4 (5) : e201900490. ScholarBank@NUS Repository. https://doi.org/10.26508/lsa.201900490
Rights: Attribution 4.0 International
Abstract: The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and ?-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets. © 2021 Zacarías-Fluck et al.
Source Title: Life Science Alliance
URI: https://scholarbank.nus.edu.sg/handle/10635/233748
ISSN: 2575-1077
DOI: 10.26508/lsa.201900490
Rights: Attribution 4.0 International
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