Please use this identifier to cite or link to this item:
Title: Colorectal cancer in patients with single versus double positive faecal immunochemical test results: A retrospective cohort study from a public tertiary hospital
Authors: Lim, Tian Zhi
Lau, Jerrald 
Wong, Gretel Jianlin 
Tan, Ker-Kan 
Issue Date: 4-Jun-2021
Publisher: Public Library of Science
Citation: Lim, Tian Zhi, Lau, Jerrald, Wong, Gretel Jianlin, Tan, Ker-Kan (2021-06-04). Colorectal cancer in patients with single versus double positive faecal immunochemical test results: A retrospective cohort study from a public tertiary hospital. PLoS ONE 16 (6-Jun) : e0250460. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background Screening for colorectal cancer (CRC) using the faecal immunochemical test (FIT) is widely advocated. Few studies have compared the rate of detecting colonoscopic pathologies in single compared to double FIT-positive follow-up colonoscopy-compliant individuals in a two-sample national FIT screening program. Objective To compare CRC incidence in double FIT-positive versus single FIT-positive individuals using a retrospective cohort of patients from a tertiary hospital in Singapore. Design Retrospective cohort study. Setting Data was extracted from one public tertiary hospital in Singapore. Participants 1,422 FIT-positive individuals from the national FIT screening program who were referred to the hospital from 1st January 2017 to 31st March 2020 for follow-up consultation and diagnostic colonoscopy. Measurements The exposure of interest was a positive result on both FIT kits. The main outcome was a follow- up diagnostic colonoscopy finding of CRC. The secondary outcome was a diagnostic colonoscopy finding of a colorectal polyp. Results Incidence density of CRC was 1.15 and 13.10 per 100,000 person-months, in the single and double FIT-positive group, respectively. This resulted in an incidence rate ratio of 11.40 (95% CI = 4.34, 35.09). Colorectal polyp detection was significantly higher (p < 0.01) in the double (103 of 173 participants; 59.5%) compared to the single (279 of 671 participants; 41.6%) FIT-positive group. Limitations The key limitation of this study was the relatively small cohort derived from a single tertiary hospital, as this had the effect of limiting the number of incident cases, resulting in comparatively imprecise CIs. Conclusions Double FIT-positive individuals are significantly more likely to have a colonoscopy finding of incident CRC or premalignant polyp than single FIT-positive individuals. Clinicians and policymakers should consider updating their CRC screening protocols accordingly. Copyright: © 2021 Lim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0250460
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1371_journal_pone_0250460.pdf358.35 kBAdobe PDF



Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons