Please use this identifier to cite or link to this item: https://doi.org/10.15252/emmm.202114045
Title: Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2
Authors: Chan, Yi-Hao
Fong, Siew-Wai 
Poh, Chek-Meng
Carissimo, Guillaume
Yeo, Nicholas Kim-Wah
Amrun, Siti Naqiah
Goh, Yun Shan
Lim, Jackwee
Xu, Weili
Chee, Rhonda Sin-Ling
Torres-Ruesta, Anthony
Lee, Cheryl Yi-Pin
Tay, Matthew Zirui
Chang, Zi Wei
Lee, Wen-Hsin
Wang, Bei
Tan, Seow-Yen
Kalimuddin, Shirin 
Young, Barnaby Edward
Leo, Yee-Sin 
Wang, Cheng-, I
Lee, Bernett
Rötzschke, Olaf
Lye, David Chien 
Renia, Laurent
Ng, Lisa F. P. 
Keywords: asymptomatic
COVID-19
disease tolerance
SARS-CoV-2
Issue Date: 27-May-2021
Publisher: John Wiley and Sons Inc
Citation: Chan, Yi-Hao, Fong, Siew-Wai, Poh, Chek-Meng, Carissimo, Guillaume, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Goh, Yun Shan, Lim, Jackwee, Xu, Weili, Chee, Rhonda Sin-Ling, Torres-Ruesta, Anthony, Lee, Cheryl Yi-Pin, Tay, Matthew Zirui, Chang, Zi Wei, Lee, Wen-Hsin, Wang, Bei, Tan, Seow-Yen, Kalimuddin, Shirin, Young, Barnaby Edward, Leo, Yee-Sin, Wang, Cheng-, I, Lee, Bernett, Rötzschke, Olaf, Lye, David Chien, Renia, Laurent, Ng, Lisa F. P. (2021-05-27). Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2. EMBO Molecular Medicine 13 (6) : e14045. ScholarBank@NUS Repository. https://doi.org/10.15252/emmm.202114045
Rights: Attribution 4.0 International
Abstract: The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro-inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro-inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus-specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS-CoV-2 was observed in asymptomatic patients. In addition, asymptomatic COVID-19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro-inflammatory and more protective immune responses against SARS-CoV-2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID-19. © 2021 The Authors. Published under the terms of the CC BY 4.0 license
Source Title: EMBO Molecular Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/233697
ISSN: 1757-4676
DOI: 10.15252/emmm.202114045
Rights: Attribution 4.0 International
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