Please use this identifier to cite or link to this item: https://doi.org/10.15252/emmm.202114045
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dc.titleAsymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2
dc.contributor.authorChan, Yi-Hao
dc.contributor.authorFong, Siew-Wai
dc.contributor.authorPoh, Chek-Meng
dc.contributor.authorCarissimo, Guillaume
dc.contributor.authorYeo, Nicholas Kim-Wah
dc.contributor.authorAmrun, Siti Naqiah
dc.contributor.authorGoh, Yun Shan
dc.contributor.authorLim, Jackwee
dc.contributor.authorXu, Weili
dc.contributor.authorChee, Rhonda Sin-Ling
dc.contributor.authorTorres-Ruesta, Anthony
dc.contributor.authorLee, Cheryl Yi-Pin
dc.contributor.authorTay, Matthew Zirui
dc.contributor.authorChang, Zi Wei
dc.contributor.authorLee, Wen-Hsin
dc.contributor.authorWang, Bei
dc.contributor.authorTan, Seow-Yen
dc.contributor.authorKalimuddin, Shirin
dc.contributor.authorYoung, Barnaby Edward
dc.contributor.authorLeo, Yee-Sin
dc.contributor.authorWang, Cheng-, I
dc.contributor.authorLee, Bernett
dc.contributor.authorRötzschke, Olaf
dc.contributor.authorLye, David Chien
dc.contributor.authorRenia, Laurent
dc.contributor.authorNg, Lisa F. P.
dc.date.accessioned2022-10-26T09:11:06Z
dc.date.available2022-10-26T09:11:06Z
dc.date.issued2021-05-27
dc.identifier.citationChan, Yi-Hao, Fong, Siew-Wai, Poh, Chek-Meng, Carissimo, Guillaume, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Goh, Yun Shan, Lim, Jackwee, Xu, Weili, Chee, Rhonda Sin-Ling, Torres-Ruesta, Anthony, Lee, Cheryl Yi-Pin, Tay, Matthew Zirui, Chang, Zi Wei, Lee, Wen-Hsin, Wang, Bei, Tan, Seow-Yen, Kalimuddin, Shirin, Young, Barnaby Edward, Leo, Yee-Sin, Wang, Cheng-, I, Lee, Bernett, Rötzschke, Olaf, Lye, David Chien, Renia, Laurent, Ng, Lisa F. P. (2021-05-27). Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2. EMBO Molecular Medicine 13 (6) : e14045. ScholarBank@NUS Repository. https://doi.org/10.15252/emmm.202114045
dc.identifier.issn1757-4676
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/233697
dc.description.abstractThe immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Systemic levels of pro-inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro-inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus-specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS-CoV-2 was observed in asymptomatic patients. In addition, asymptomatic COVID-19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro-inflammatory and more protective immune responses against SARS-CoV-2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID-19. © 2021 The Authors. Published under the terms of the CC BY 4.0 license
dc.publisherJohn Wiley and Sons Inc
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectasymptomatic
dc.subjectCOVID-19
dc.subjectdisease tolerance
dc.subjectSARS-CoV-2
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentMEDICINE
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.15252/emmm.202114045
dc.description.sourcetitleEMBO Molecular Medicine
dc.description.volume13
dc.description.issue6
dc.description.pagee14045
dc.published.statePublished
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