Please use this identifier to cite or link to this item: https://doi.org/10.1039/d1sc02896k
Title: Decarboxylative 1,4-carbocyanation of 1,3-enynes to access tetra-substituted allenesviacopper/photoredox dual catalysis
Authors: Chen, Ya 
Wang, Junjie
Lu, Yixin 
Issue Date: 1-Jan-2021
Publisher: Royal Society of Chemistry
Citation: Chen, Ya, Wang, Junjie, Lu, Yixin (2021-01-01). Decarboxylative 1,4-carbocyanation of 1,3-enynes to access tetra-substituted allenesviacopper/photoredox dual catalysis. Chemical Science 12 (34) : 11316-11321. ScholarBank@NUS Repository. https://doi.org/10.1039/d1sc02896k
Rights: Attribution 4.0 International
Abstract: We disclose herein the first example of merging photoredox catalysis and copper catalysis for radical 1,4-carbocyanations of 1,3-enynes. AlkylN-hydroxyphthalimide esters are utilized as radical precursors, and the reported mild and redox-neutral protocol has broad substrate scope and remarkable functional group tolerance. This strategy allows for the synthesis of diverse multi-substituted allenes with high chemo- and regio-selectivities, also permitting late stage allenylation of natural products and drug molecules. © The Royal Society of Chemistry 2021.
Source Title: Chemical Science
URI: https://scholarbank.nus.edu.sg/handle/10635/233644
ISSN: 2041-6520
DOI: 10.1039/d1sc02896k
Rights: Attribution 4.0 International
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