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Title: Regiodivergent sulfonylarylation of 1,3-enynes: Via nickel/photoredox dual catalysis
Authors: Chen, Ya 
Zhu, Kun
Huang, Qingqin
Lu, Yixin 
Issue Date: 1-Jan-2021
Publisher: Royal Society of Chemistry
Citation: Chen, Ya, Zhu, Kun, Huang, Qingqin, Lu, Yixin (2021-01-01). Regiodivergent sulfonylarylation of 1,3-enynes: Via nickel/photoredox dual catalysis. Chemical Science 12 (40) : 13564-13571. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Catalytic difunctionalization of 1,3-enynes represents an efficient and versatile approach to rapidly assemble multifunctional propargylic compounds, allenes and 1,3-dienes. Controlling selectivity in such addition reactions has been a long-standing challenging task due to multiple reactive centers resulting from the conjugated structure of 1,3-enynes. Herein, we present a straightforward method for regiodivergent sulfonylarylation of 1,3-enynes via dual nickel and photoredox catalysis. Hinging on the nature of 1,3-enynes, diverse reaction pathways are feasible: synthesis of ?-allenyl sulfones via 1,4-sulfonylarylation, or preparation of (E)-1,3-dienyl sulfones with high chemo-, regio- and stereoselectivity through 3,4-sulfonylarylation. Notably, this is the first example that nickel and photoredox catalysis are merged to achieve efficient and versatile difunctionalization of 1,3-enynes. © The Royal Society of Chemistry.
Source Title: Chemical Science
ISSN: 2041-6520
DOI: 10.1039/d1sc04320j
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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