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https://doi.org/10.1364/boe.426218
Title: | Full circumferential morphological analysis of Schlemm’s canal in human eyes using megahertz swept source OCT | Authors: | Yao, Xinwen Tan, Bingyao Ho, Yijie Liu, Xinyu Wong, Damon Chua, Jacqueline Wong, Tina T. Perera, Shamira Ang, Marcus Werkmeister, Rene M. Schmetterer, Leopold |
Issue Date: | 7-Jun-2021 | Publisher: | The Optical Society | Citation: | Yao, Xinwen, Tan, Bingyao, Ho, Yijie, Liu, Xinyu, Wong, Damon, Chua, Jacqueline, Wong, Tina T., Perera, Shamira, Ang, Marcus, Werkmeister, Rene M., Schmetterer, Leopold (2021-06-07). Full circumferential morphological analysis of Schlemm’s canal in human eyes using megahertz swept source OCT. Biomedical Optics Express 12 (7) : 3865-3877. ScholarBank@NUS Repository. https://doi.org/10.1364/boe.426218 | Rights: | Attribution 4.0 International | Abstract: | We performed full circumferential imaging of the Schlemm’s canal (SC) of two human eyes using a Fourier domain mode-lock laser (FDML) based 1.66-MHz SS-OCT prototype at 1060 nm. Eight volumes with overlapping margins were acquired around the limbal area with customized raster scanning patterns designed to fully cover the SC while minimizing motion artifacts. The SC was segmented from the volumes using a semi-automated active contour segmentation algorithm, whose mean dice similarity coefficient was 0.76 compared to the manual segmentation results. We also reconstructed three-dimensional (3D) renderings of the 360° SC by stitching the segmented SCs from the volumetric datasets. Quantitative metrics of the full circumferential SC were provided, including the mean and standard deviation (SD) of the cross-sectional area (CSA), the maximum CSA, the minimum and maximum SC opening width, and the number of collector channels (CC) stemming from the SC. © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement | Source Title: | Biomedical Optics Express | URI: | https://scholarbank.nus.edu.sg/handle/10635/233169 | ISSN: | 2156-7085 | DOI: | 10.1364/boe.426218 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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