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Title: Full circumferential morphological analysis of Schlemm’s canal in human eyes using megahertz swept source OCT
Authors: Yao, Xinwen
Tan, Bingyao
Ho, Yijie
Liu, Xinyu
Wong, Damon
Chua, Jacqueline 
Wong, Tina T. 
Perera, Shamira 
Ang, Marcus 
Werkmeister, Rene M.
Schmetterer, Leopold 
Issue Date: 7-Jun-2021
Publisher: The Optical Society
Citation: Yao, Xinwen, Tan, Bingyao, Ho, Yijie, Liu, Xinyu, Wong, Damon, Chua, Jacqueline, Wong, Tina T., Perera, Shamira, Ang, Marcus, Werkmeister, Rene M., Schmetterer, Leopold (2021-06-07). Full circumferential morphological analysis of Schlemm’s canal in human eyes using megahertz swept source OCT. Biomedical Optics Express 12 (7) : 3865-3877. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: We performed full circumferential imaging of the Schlemm’s canal (SC) of two human eyes using a Fourier domain mode-lock laser (FDML) based 1.66-MHz SS-OCT prototype at 1060 nm. Eight volumes with overlapping margins were acquired around the limbal area with customized raster scanning patterns designed to fully cover the SC while minimizing motion artifacts. The SC was segmented from the volumes using a semi-automated active contour segmentation algorithm, whose mean dice similarity coefficient was 0.76 compared to the manual segmentation results. We also reconstructed three-dimensional (3D) renderings of the 360° SC by stitching the segmented SCs from the volumetric datasets. Quantitative metrics of the full circumferential SC were provided, including the mean and standard deviation (SD) of the cross-sectional area (CSA), the maximum CSA, the minimum and maximum SC opening width, and the number of collector channels (CC) stemming from the SC. © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Source Title: Biomedical Optics Express
ISSN: 2156-7085
DOI: 10.1364/boe.426218
Rights: Attribution 4.0 International
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