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Title: A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
Authors: Hua, Yue
Wang, Yuan
Kang, Xue
Xu, Fan
Han, Zhen
Zhang, Chong
Wang, Zhao-Yang
Liu, Jun-Qi
Zhao, Xueli
Chen, Xiaoyuan 
Zang, Shuang-Quan
Keywords: Aggregation-induced emission (AIE)
Fenton reaction
Issue Date: 1-Dec-2021
Publisher: BioMed Central Ltd
Citation: Hua, Yue, Wang, Yuan, Kang, Xue, Xu, Fan, Han, Zhen, Zhang, Chong, Wang, Zhao-Yang, Liu, Jun-Qi, Zhao, Xueli, Chen, Xiaoyuan, Zang, Shuang-Quan (2021-12-01). A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy. Journal of Nanobiotechnology 19 (1) : 438. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: As cancer is one of the main leading causes of mortality, a series of monotherapies such as chemotherapy, gene therapy and radiotherapy have been developed to overcome this thorny problem. However, a single treatment approach could not achieve satisfactory effect in many experimental explorations. Results: In this study, we report the fabrication of cyclic RGD peptide (cRGD) modified Au4-iron oxide nanoparticle (Au4-IO NP-cRGD) based on aggregation-induced emission (AIE) as a multifunctional theranostic system. Besides Au4 cluster-based fluorescence imaging and enhanced radiotherapy, iron oxide (IO) nanocluster could realize magnetic resonance (MR) imaging and Fenton reaction-based chemotherapy. Abundant toxic reactive oxygen species generated from X-ray irradiation and in situ tumor-specific Fenton reaction under acidic microenvironment leads to the apoptotic and necrotic death of cancer cells. In vivo studies demonstrated good biocompatibility of Au4-IO NP-cRGD and a high tumor suppression rate of 81.1% in the synergistic therapy group. Conclusions: The successful dual-modal imaging and combined tumor therapy demonstrated AIE as a promising strategy for constructing multifunctional cancer theranostic platform. Graphical Abstract: [Figure not available: see fulltext.]. © 2021, The Author(s).
Source Title: Journal of Nanobiotechnology
ISSN: 1477-3155
DOI: 10.1186/s12951-021-01191-x
Rights: Attribution 4.0 International
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