Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12951-021-01191-x
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dc.titleA multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy
dc.contributor.authorHua, Yue
dc.contributor.authorWang, Yuan
dc.contributor.authorKang, Xue
dc.contributor.authorXu, Fan
dc.contributor.authorHan, Zhen
dc.contributor.authorZhang, Chong
dc.contributor.authorWang, Zhao-Yang
dc.contributor.authorLiu, Jun-Qi
dc.contributor.authorZhao, Xueli
dc.contributor.authorChen, Xiaoyuan
dc.contributor.authorZang, Shuang-Quan
dc.date.accessioned2022-10-13T06:41:11Z
dc.date.available2022-10-13T06:41:11Z
dc.date.issued2021-12-01
dc.identifier.citationHua, Yue, Wang, Yuan, Kang, Xue, Xu, Fan, Han, Zhen, Zhang, Chong, Wang, Zhao-Yang, Liu, Jun-Qi, Zhao, Xueli, Chen, Xiaoyuan, Zang, Shuang-Quan (2021-12-01). A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy. Journal of Nanobiotechnology 19 (1) : 438. ScholarBank@NUS Repository. https://doi.org/10.1186/s12951-021-01191-x
dc.identifier.issn1477-3155
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/233004
dc.description.abstractBackground: As cancer is one of the main leading causes of mortality, a series of monotherapies such as chemotherapy, gene therapy and radiotherapy have been developed to overcome this thorny problem. However, a single treatment approach could not achieve satisfactory effect in many experimental explorations. Results: In this study, we report the fabrication of cyclic RGD peptide (cRGD) modified Au4-iron oxide nanoparticle (Au4-IO NP-cRGD) based on aggregation-induced emission (AIE) as a multifunctional theranostic system. Besides Au4 cluster-based fluorescence imaging and enhanced radiotherapy, iron oxide (IO) nanocluster could realize magnetic resonance (MR) imaging and Fenton reaction-based chemotherapy. Abundant toxic reactive oxygen species generated from X-ray irradiation and in situ tumor-specific Fenton reaction under acidic microenvironment leads to the apoptotic and necrotic death of cancer cells. In vivo studies demonstrated good biocompatibility of Au4-IO NP-cRGD and a high tumor suppression rate of 81.1% in the synergistic therapy group. Conclusions: The successful dual-modal imaging and combined tumor therapy demonstrated AIE as a promising strategy for constructing multifunctional cancer theranostic platform. Graphical Abstract: [Figure not available: see fulltext.]. © 2021, The Author(s).
dc.publisherBioMed Central Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectAggregation-induced emission (AIE)
dc.subjectAssemblies
dc.subjectFenton reaction
dc.subjectRadiosensitizer
dc.subjectTherapy
dc.typeArticle
dc.contributor.departmentDEPT OF DIAGNOSTIC RADIOLOGY
dc.description.doi10.1186/s12951-021-01191-x
dc.description.sourcetitleJournal of Nanobiotechnology
dc.description.volume19
dc.description.issue1
dc.description.page438
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