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Title: Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non–Indocyanine Green Angiograph Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup
Authors: Cheung, Chui M. 
Lai, Timothy Y. Y.
Teo, Kelvin 
Ruamviboonsuk, Paisan
Chen, Shih-Jen
Kim, Judy E.
Gomi, Fumi
Koh, Adrian H. 
Kokame, Gregg
Jordan-Yu, Janice Marie
Corvi, Federico
Invernizzi, Alessandro
Ogura, Yuichiro
Tan, Colin
Mitchell, Paul
Gupta, Vishali
Chhablani, Jay
Chakravarthy, Usha
Sadda, Srinivas R.
Wong, Tien Y. 
Staurenghi, Giovanni
Lee, Won Ki
Keywords: Accuracy
Polypoidal choroidal vasculopathy
Sensitivity and specificity
Issue Date: 1-Mar-2021
Publisher: Elsevier Inc.
Citation: Cheung, Chui M., Lai, Timothy Y. Y., Teo, Kelvin, Ruamviboonsuk, Paisan, Chen, Shih-Jen, Kim, Judy E., Gomi, Fumi, Koh, Adrian H., Kokame, Gregg, Jordan-Yu, Janice Marie, Corvi, Federico, Invernizzi, Alessandro, Ogura, Yuichiro, Tan, Colin, Mitchell, Paul, Gupta, Vishali, Chhablani, Jay, Chakravarthy, Usha, Sadda, Srinivas R., Wong, Tien Y., Staurenghi, Giovanni, Lee, Won Ki (2021-03-01). Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non–Indocyanine Green Angiograph Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup. Ophthalmology 128 (3) : 443-452. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Purpose: To develop consensus terminology in the setting of polypoidal choroidal vasculopathy (PCV) and to develop and validate a set of diagnostic criteria not requiring indocyanine green angiography (ICGA) for differentiating PCV from typical neovascular age-related macular degeneration (nAMD) based on a combination of OCT and color fundus photography findings. Design: Evaluation of diagnostic test results. Participants: Panel of retina specialists. Methods: As part of the Asia-Pacific Ocular Imaging Society, an international group of experts surveyed and discussed the published literature regarding the current nomenclature and lesion components for PCV, and proposed an updated consensus nomenclature that reflects our latest understanding based on imaging and histologic reports. The workgroup evaluated a set of diagnostic features based on OCT images and color fundus photographs for PCV that may distinguish it from typical nAMD and assessed the performance of individual and combinations of these non-ICGA features, aiming to propose a new set of diagnostic criteria that does not require the use of ICGA. The final recommendation was validated in 80 eyes from 2 additional cohorts. Main Outcome Measures: Consensus nomenclature system for PCV lesion components and non–ICGA-based criteria to differentiate PCV from typical nAMD. Results: The workgroup recommended the terms polypoidal lesion and branching neovascular network for the 2 key lesion components in PCV. For the diagnosis of PCV, the combination of 3 OCT-based major criteria (sub–retinal pigment epithelium [RPE] ring-like lesion, en face OCT complex RPE elevation, and sharp-peaked PED) achieved an area under the receiver operating characteristic curve of 0.90. Validation of this new scheme in a separate subset 80 eyes achieved an accuracy of 82%. Conclusions: We propose updated terminology for PCV lesion components that better reflects the nature of these lesions and is based on international consensus. A set of practical diagnostic criteria applied easily to spectral-domain OCT results can be used for diagnosing PCV with high accuracy in clinical settings in which ICGA is not performed routinely. © 2020 American Academy of Ophthalmology
Source Title: Ophthalmology
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2020.08.006
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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