Please use this identifier to cite or link to this item: https://doi.org/10.18632/aging.202563
Title: Commonalities in Biomarkers and Phenotypes Between Mild Cognitive Impairment and Cerebral Palsy: A Pilot Exploratory Study
Authors: Siang Ng, T.K.
Tagawa, A.
Chun-Man Ho, R. 
Larbi, A.
Kua, E.H. 
Mahendran, R. 
Carollo, J.J.
Heyn, P.C.
Keywords: aging model
biomarker
cerebral palsy
community-dwelling older adults
comparative study
Issue Date: 26-Jan-2021
Publisher: Impact Journals LLC
Citation: Siang Ng, T.K., Tagawa, A., Chun-Man Ho, R., Larbi, A., Kua, E.H., Mahendran, R., Carollo, J.J., Heyn, P.C. (2021-01-26). Commonalities in Biomarkers and Phenotypes Between Mild Cognitive Impairment and Cerebral Palsy: A Pilot Exploratory Study. Aging 13 (2) : 1773-1816. ScholarBank@NUS Repository. https://doi.org/10.18632/aging.202563
Rights: Attribution 4.0 International
Abstract: Clinically, individuals with cerebral palsy (CP) experience symptoms of accelerated biological aging. Accumulative deficits in both molecular underpinnings and functions in young adults with CP can lead to premature aging, such as heart disease and mild cognitive impairment (MCI). MCI is an intermediate stage between healthy aging and dementia that normally develops at old age. Owing to their intriguingly parallel yet “inverted” disease trajectories, CP might share similar pathology and phenotypes with MCI, conferring increased risk for developing dementia at a much younger age. Thus, we examined this hypothesis by evaluating these two distinct populations (MCI= 55, CP = 72). A total of nine measures (e.g., blood biomarkers, neurocognition, Framingham Heart Study Score (FHSS) were compared between the groups. Compared to MCI, upon controlling for covariates, delta FHSS, brain-derived neurotrophic factor (BDNF) levels, and systolic blood pressure were significantly lower in CP. Intriguingly, high-sensitivity CRP, several metabolic outcomes, and neurocognitive function were similar between the two groups. This study supports a shared biological underpinning and key phenotypes between CP and MCI. Thus, we proposed a double-hit model for the development of premature aging outcomes in CP through shared biomarkers. Future longitudinal follow-up studies are warranted to examine accelerated biological aging. © 2021 Ng et al
Source Title: Aging
URI: https://scholarbank.nus.edu.sg/handle/10635/232875
ISSN: 1945-4589
DOI: 10.18632/aging.202563
Rights: Attribution 4.0 International
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