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https://doi.org/10.18632/aging.202563
Title: | Commonalities in Biomarkers and Phenotypes Between Mild Cognitive Impairment and Cerebral Palsy: A Pilot Exploratory Study | Authors: | Siang Ng, T.K. Tagawa, A. Chun-Man Ho, R. Larbi, A. Kua, E.H. Mahendran, R. Carollo, J.J. Heyn, P.C. |
Keywords: | aging model biomarker cerebral palsy community-dwelling older adults comparative study |
Issue Date: | 26-Jan-2021 | Publisher: | Impact Journals LLC | Citation: | Siang Ng, T.K., Tagawa, A., Chun-Man Ho, R., Larbi, A., Kua, E.H., Mahendran, R., Carollo, J.J., Heyn, P.C. (2021-01-26). Commonalities in Biomarkers and Phenotypes Between Mild Cognitive Impairment and Cerebral Palsy: A Pilot Exploratory Study. Aging 13 (2) : 1773-1816. ScholarBank@NUS Repository. https://doi.org/10.18632/aging.202563 | Rights: | Attribution 4.0 International | Abstract: | Clinically, individuals with cerebral palsy (CP) experience symptoms of accelerated biological aging. Accumulative deficits in both molecular underpinnings and functions in young adults with CP can lead to premature aging, such as heart disease and mild cognitive impairment (MCI). MCI is an intermediate stage between healthy aging and dementia that normally develops at old age. Owing to their intriguingly parallel yet “inverted” disease trajectories, CP might share similar pathology and phenotypes with MCI, conferring increased risk for developing dementia at a much younger age. Thus, we examined this hypothesis by evaluating these two distinct populations (MCI= 55, CP = 72). A total of nine measures (e.g., blood biomarkers, neurocognition, Framingham Heart Study Score (FHSS) were compared between the groups. Compared to MCI, upon controlling for covariates, delta FHSS, brain-derived neurotrophic factor (BDNF) levels, and systolic blood pressure were significantly lower in CP. Intriguingly, high-sensitivity CRP, several metabolic outcomes, and neurocognitive function were similar between the two groups. This study supports a shared biological underpinning and key phenotypes between CP and MCI. Thus, we proposed a double-hit model for the development of premature aging outcomes in CP through shared biomarkers. Future longitudinal follow-up studies are warranted to examine accelerated biological aging. © 2021 Ng et al | Source Title: | Aging | URI: | https://scholarbank.nus.edu.sg/handle/10635/232875 | ISSN: | 1945-4589 | DOI: | 10.18632/aging.202563 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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