Please use this identifier to cite or link to this item:
Title: dRTEL1 is essential for the maintenance of Drosophila male germline stem cells
Authors: Yang, Ying
Kong, Ruiyan
Goh, Feng Guang
Somers, W. Gregory
Hime, Gary R.
Li, Zhouhua
Cai, Yu 
Issue Date: 13-Oct-2021
Publisher: Public Library of Science
Citation: Yang, Ying, Kong, Ruiyan, Goh, Feng Guang, Somers, W. Gregory, Hime, Gary R., Li, Zhouhua, Cai, Yu (2021-10-13). dRTEL1 is essential for the maintenance of Drosophila male germline stem cells. PLoS Genetics 17 (10) : e1009834. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain unanswered. In this study, we identify dRTEL1, the Drosophila homolog of Regulator of Telomere Elongation Helicase 1, as a novel regulator of male germline stem cells (GSCs). Our genome-wide transcriptome analysis and ChIP-Seq results suggest that dRTEL1 affects a set of candidate genes required for GSC maintenance, likely independent of its role in DNA repair. Furthermore, dRTEL1 prevents DNA damage-induced checkpoint activation in GSCs. Finally, dRTEL1 functions to sustain Stat92E protein levels, the key player in GSC maintenance. Together, our findings reveal an intrinsic role of the DNA helicase dRTEL1 in maintaining male GSC and provide insight into the function of dRTEL1. Copyright: © 2021 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS Genetics
ISSN: 1553-7390
DOI: 10.1371/journal.pgen.1009834
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1371_journal_pgen_1009834.pdf7.96 MBAdobe PDF



Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons