Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pgen.1009834
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dc.titledRTEL1 is essential for the maintenance of Drosophila male germline stem cells
dc.contributor.authorYang, Ying
dc.contributor.authorKong, Ruiyan
dc.contributor.authorGoh, Feng Guang
dc.contributor.authorSomers, W. Gregory
dc.contributor.authorHime, Gary R.
dc.contributor.authorLi, Zhouhua
dc.contributor.authorCai, Yu
dc.date.accessioned2022-10-13T01:11:43Z
dc.date.available2022-10-13T01:11:43Z
dc.date.issued2021-10-13
dc.identifier.citationYang, Ying, Kong, Ruiyan, Goh, Feng Guang, Somers, W. Gregory, Hime, Gary R., Li, Zhouhua, Cai, Yu (2021-10-13). dRTEL1 is essential for the maintenance of Drosophila male germline stem cells. PLoS Genetics 17 (10) : e1009834. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1009834
dc.identifier.issn1553-7390
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232798
dc.description.abstractStem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain unanswered. In this study, we identify dRTEL1, the Drosophila homolog of Regulator of Telomere Elongation Helicase 1, as a novel regulator of male germline stem cells (GSCs). Our genome-wide transcriptome analysis and ChIP-Seq results suggest that dRTEL1 affects a set of candidate genes required for GSC maintenance, likely independent of its role in DNA repair. Furthermore, dRTEL1 prevents DNA damage-induced checkpoint activation in GSCs. Finally, dRTEL1 functions to sustain Stat92E protein levels, the key player in GSC maintenance. Together, our findings reveal an intrinsic role of the DNA helicase dRTEL1 in maintaining male GSC and provide insight into the function of dRTEL1. Copyright: © 2021 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1371/journal.pgen.1009834
dc.description.sourcetitlePLoS Genetics
dc.description.volume17
dc.description.issue10
dc.description.pagee1009834
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