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https://doi.org/10.1186/s12957-021-02125-5
Title: | Chemotherapy and adverse cardiovascular events in colorectal cancer patients undergoing surgical resection | Authors: | Koo, Chieh Yang Tai, Bee-Choo Chan, Dedrick Kok Hong Tan, Li Ling Tan, Ker Kan Lee, Chi-Hang |
Keywords: | Cancer survivors Cardio-oncology Cardio-toxicity Coronary artery disease Preventive medicine |
Issue Date: | 21-Jan-2021 | Publisher: | BioMed Central Ltd | Citation: | Koo, Chieh Yang, Tai, Bee-Choo, Chan, Dedrick Kok Hong, Tan, Li Ling, Tan, Ker Kan, Lee, Chi-Hang (2021-01-21). Chemotherapy and adverse cardiovascular events in colorectal cancer patients undergoing surgical resection. World Journal of Surgical Oncology 19 (1) : 21. ScholarBank@NUS Repository. https://doi.org/10.1186/s12957-021-02125-5 | Rights: | Attribution 4.0 International | Abstract: | Abstract: Background: Colorectal cancer patients undergoing surgical resection are at increased short-term risk of post-operative adverse events. However, specific predictors for long-term major adverse cardiac and cerebrovascular events (MACCE) are unclear. We hypothesised that patients who receive chemotherapy are at higher risk of MACCE than those who did not. Methods: In this retrospective study, 412 patients who underwent surgical resection for newly diagnosed colorectal cancer from January 2013 to April 2015 were grouped according to chemotherapy status. MACCE was defined as a composite of cardiovascular death, myocardial infarction, stroke, unplanned revascularisation, hospitalisation for heart failure or angina. Predictors of MACCE were identified using competing risks regression, with non-cardiovascular death a competing risk. Results: There were 200 patients in the chemotherapy group and 212 patients in the non-chemotherapy group. The overall prevalence of prior cardiovascular disease was 20.9%. Over a median follow-up duration of 5.1 years from diagnosis, the incidence of MACCE was 13.3%. Diabetes mellitus and prior cardiovascular disease were associated with an increased risk of MACCE (subdistribution hazard ratio, 2.56; 95% CI, 1.48-4.42) and 2.38 (95% CI, 1.36-4.18) respectively. The chemotherapy group was associated with a lower risk of MACCE (subdistribution hazard ratio, 0.37; 95% CI, 0.19-0.75) compared to the non-chemotherapy group. Conclusions: Amongst colorectal cancer patients undergoing surgical resection, there was a high incidence of MACCE. Diabetes mellitus and prior cardiovascular disease were associated with an increased risk of MACCE. Chemotherapy was associated with a lower risk of MACCE, but further research is required to clarify this association. © 2021, The Author(s). | Source Title: | World Journal of Surgical Oncology | URI: | https://scholarbank.nus.edu.sg/handle/10635/232769 | ISSN: | 1477-7819 | DOI: | 10.1186/s12957-021-02125-5 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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