Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s12957-021-02125-5
DC Field | Value | |
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dc.title | Chemotherapy and adverse cardiovascular events in colorectal cancer patients undergoing surgical resection | |
dc.contributor.author | Koo, Chieh Yang | |
dc.contributor.author | Tai, Bee-Choo | |
dc.contributor.author | Chan, Dedrick Kok Hong | |
dc.contributor.author | Tan, Li Ling | |
dc.contributor.author | Tan, Ker Kan | |
dc.contributor.author | Lee, Chi-Hang | |
dc.date.accessioned | 2022-10-13T01:09:47Z | |
dc.date.available | 2022-10-13T01:09:47Z | |
dc.date.issued | 2021-01-21 | |
dc.identifier.citation | Koo, Chieh Yang, Tai, Bee-Choo, Chan, Dedrick Kok Hong, Tan, Li Ling, Tan, Ker Kan, Lee, Chi-Hang (2021-01-21). Chemotherapy and adverse cardiovascular events in colorectal cancer patients undergoing surgical resection. World Journal of Surgical Oncology 19 (1) : 21. ScholarBank@NUS Repository. https://doi.org/10.1186/s12957-021-02125-5 | |
dc.identifier.issn | 1477-7819 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/232769 | |
dc.description.abstract | Abstract: Background: Colorectal cancer patients undergoing surgical resection are at increased short-term risk of post-operative adverse events. However, specific predictors for long-term major adverse cardiac and cerebrovascular events (MACCE) are unclear. We hypothesised that patients who receive chemotherapy are at higher risk of MACCE than those who did not. Methods: In this retrospective study, 412 patients who underwent surgical resection for newly diagnosed colorectal cancer from January 2013 to April 2015 were grouped according to chemotherapy status. MACCE was defined as a composite of cardiovascular death, myocardial infarction, stroke, unplanned revascularisation, hospitalisation for heart failure or angina. Predictors of MACCE were identified using competing risks regression, with non-cardiovascular death a competing risk. Results: There were 200 patients in the chemotherapy group and 212 patients in the non-chemotherapy group. The overall prevalence of prior cardiovascular disease was 20.9%. Over a median follow-up duration of 5.1 years from diagnosis, the incidence of MACCE was 13.3%. Diabetes mellitus and prior cardiovascular disease were associated with an increased risk of MACCE (subdistribution hazard ratio, 2.56; 95% CI, 1.48-4.42) and 2.38 (95% CI, 1.36-4.18) respectively. The chemotherapy group was associated with a lower risk of MACCE (subdistribution hazard ratio, 0.37; 95% CI, 0.19-0.75) compared to the non-chemotherapy group. Conclusions: Amongst colorectal cancer patients undergoing surgical resection, there was a high incidence of MACCE. Diabetes mellitus and prior cardiovascular disease were associated with an increased risk of MACCE. Chemotherapy was associated with a lower risk of MACCE, but further research is required to clarify this association. © 2021, The Author(s). | |
dc.publisher | BioMed Central Ltd | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | Cancer survivors | |
dc.subject | Cardio-oncology | |
dc.subject | Cardio-toxicity | |
dc.subject | Coronary artery disease | |
dc.subject | Preventive medicine | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.contributor.department | SURGERY | |
dc.description.doi | 10.1186/s12957-021-02125-5 | |
dc.description.sourcetitle | World Journal of Surgical Oncology | |
dc.description.volume | 19 | |
dc.description.issue | 1 | |
dc.description.page | 21 | |
Appears in Collections: | Elements Staff Publications |
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