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Title: The roles of carotenoid consumption and bioavailability in cardiovascular health
Authors: Yao, Yuanhang
Goh, Hongyi Manfred
Kim, Jung Eun 
Keywords: Bioavailability
Cardiovascular disease
Oxidative stress
Vascular health
Issue Date: 11-Dec-2021
Publisher: MDPI
Citation: Yao, Yuanhang, Goh, Hongyi Manfred, Kim, Jung Eun (2021-12-11). The roles of carotenoid consumption and bioavailability in cardiovascular health. Antioxidants 10 (12) : 1978. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Carotenoids are natural pigments generally with a polyene chain consisting of 9–11 double bonds. In recent years, there has been increasing research interest in carotenoids because of their protective roles in cardiovascular diseases (CVDs). While the consumption of carotenoids may have a beneficial effect on CVDs, the literature shows inconsistencies between carotenoid consumption and reductions in the risk of CVDs. Therefore, this review aims to provide a summary of the association between dietary carotenoid intake and the risk of CVDs from published epidemiological studies. Meanwhile, to further elucidate the roles of carotenoid intake in CVD protection, this review outlines the evidence reporting the effects of carotenoids on cardiovascular health from randomized controlled trials by assessing classical CVD risk factors, oxidative stress, inflammatory markers and vascular health-related parameters, respectively. Given the considerable discrepancies among the published results, this review underlines the importance of bioavailability and summarizes the current dietary strategies for improving the bioavailability of carotenoids. In conclusion, this review supports the protective roles of carotenoids against CVDs, possibly by attenuating oxidative stress and mitigating inflammatory response. In addition, this review suggests that the bioavailability of carotenoids should be considered when evaluating the roles of carotenoids in CVD protection. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Antioxidants
ISSN: 2076-3921
DOI: 10.3390/antiox10121978
Rights: Attribution 4.0 International
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