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Title: Genetic variation in the oxytocin system and its link to social motivation in human infants
Authors: Krol, Kathleen M.
Namaky, Nauder
Monakhov, Mikhail, V 
Lai Poh San 
Ebstein, Richard 
Grossmann, Tobias
Keywords: Emotion
Frontal asymmetry
Issue Date: 1-Sep-2021
Publisher: Elsevier Ltd
Citation: Krol, Kathleen M., Namaky, Nauder, Monakhov, Mikhail, V, Lai Poh San, Ebstein, Richard, Grossmann, Tobias (2021-09-01). Genetic variation in the oxytocin system and its link to social motivation in human infants. Psychoneuroendocrinology 131 : 105290. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Frontal brain asymmetry has been linked to motivational processes in infants and adults, with left lateralization reflecting motivation to approach and right lateralization reflecting motivation to withdraw. We examined the hypothesis that variability in infants’ social motivation may be linked to genetic variation in the oxytocin system. Eleven-month-old infants’ brain responses and looking preferences to smiling and frowning individuals were assessed in conjunction with a polymorphism in CD38 (rs3796863) linked to autism spectrum disorder (ASD) and reduced oxytocin. Frontal brain asymmetry and looking preferences differed as a function of CD38 genotype. While non-risk A-allele carriers displayed left lateralization to smiling faces (approach) and a heightened looking preference for the individual who smiled, infants with the CC (ASD risk) genotype displayed withdrawal from smiling faces and a preference for the individual who frowned. Findings demonstrate that the oxytocin system is linked to brain and behavioral markers of social motivation in infancy. © 2021 The Authors
Source Title: Psychoneuroendocrinology
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2021.105290
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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