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Title: Extracellular vesicle-associated organotropic metastasis
Authors: Mo, Zhenzhen
Cheong, Jia Yang Alex
Xiang, Lirong
Le, Minh T. N. 
Grimson, Andrew
Zhang, Daniel Xin
Keywords: cancer
extracellular vesicles
Issue Date: 3-Nov-2020
Publisher: Blackwell Publishing Ltd
Citation: Mo, Zhenzhen, Cheong, Jia Yang Alex, Xiang, Lirong, Le, Minh T. N., Grimson, Andrew, Zhang, Daniel Xin (2020-11-03). Extracellular vesicle-associated organotropic metastasis. Cell Proliferation 54 (1) : e12948. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Metastasis refers to the progressive dissemination of primary tumour cells and their colonization of other tissues and is associated with most cancer-related mortalities. The disproportional and systematic distribution pattern of distant metastasis in different cancers has been well documented, as is termed metastatic organotropism, a process orchestrated by a combination of anatomical, pathophysiological, genetic and biochemical factors. Extracellular vesicles (EVs), nanosized cell-derived membrane-bound particles known to mediate intercellular communication, are now considered crucial in organ-specific metastasis. Here, we review and summarize recent findings regarding EV-associated organotropic metastasis as well as some of the general mechanisms by which EVs contribute to this important process in cancer and provide a future perspective on this emerging topic. We highlight studies that demonstrate a role of tumour-derived EVs in organotropic metastasis via pre-metastatic niche modulation. The bioactive cargo carried by EVs is of diagnostic and prognostic values, and counteracting the functions of such EVs may be a novel therapeutic strategy targeting metastasis. Further investigations are warranted to better understand the functions and mechanisms of EVs in organotropic metastasis and accelerate the relevant clinical translation. © 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.
Source Title: Cell Proliferation
ISSN: 0960-7722
DOI: 10.1111/cpr.12948
Rights: Attribution 4.0 International
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