Please use this identifier to cite or link to this item:
https://doi.org/10.1111/cpr.12948
DC Field | Value | |
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dc.title | Extracellular vesicle-associated organotropic metastasis | |
dc.contributor.author | Mo, Zhenzhen | |
dc.contributor.author | Cheong, Jia Yang Alex | |
dc.contributor.author | Xiang, Lirong | |
dc.contributor.author | Le, Minh T. N. | |
dc.contributor.author | Grimson, Andrew | |
dc.contributor.author | Zhang, Daniel Xin | |
dc.date.accessioned | 2022-10-12T08:13:16Z | |
dc.date.available | 2022-10-12T08:13:16Z | |
dc.date.issued | 2020-11-03 | |
dc.identifier.citation | Mo, Zhenzhen, Cheong, Jia Yang Alex, Xiang, Lirong, Le, Minh T. N., Grimson, Andrew, Zhang, Daniel Xin (2020-11-03). Extracellular vesicle-associated organotropic metastasis. Cell Proliferation 54 (1) : e12948. ScholarBank@NUS Repository. https://doi.org/10.1111/cpr.12948 | |
dc.identifier.issn | 0960-7722 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/232563 | |
dc.description.abstract | Metastasis refers to the progressive dissemination of primary tumour cells and their colonization of other tissues and is associated with most cancer-related mortalities. The disproportional and systematic distribution pattern of distant metastasis in different cancers has been well documented, as is termed metastatic organotropism, a process orchestrated by a combination of anatomical, pathophysiological, genetic and biochemical factors. Extracellular vesicles (EVs), nanosized cell-derived membrane-bound particles known to mediate intercellular communication, are now considered crucial in organ-specific metastasis. Here, we review and summarize recent findings regarding EV-associated organotropic metastasis as well as some of the general mechanisms by which EVs contribute to this important process in cancer and provide a future perspective on this emerging topic. We highlight studies that demonstrate a role of tumour-derived EVs in organotropic metastasis via pre-metastatic niche modulation. The bioactive cargo carried by EVs is of diagnostic and prognostic values, and counteracting the functions of such EVs may be a novel therapeutic strategy targeting metastasis. Further investigations are warranted to better understand the functions and mechanisms of EVs in organotropic metastasis and accelerate the relevant clinical translation. © 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | cancer | |
dc.subject | exosomes | |
dc.subject | extracellular vesicles | |
dc.subject | metastasis | |
dc.subject | microvesicles | |
dc.subject | organotropism | |
dc.type | Review | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1111/cpr.12948 | |
dc.description.sourcetitle | Cell Proliferation | |
dc.description.volume | 54 | |
dc.description.issue | 1 | |
dc.description.page | e12948 | |
Appears in Collections: | Elements Staff Publications |
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