Please use this identifier to cite or link to this item: https://doi.org/10.3390/microorganisms9040702
Title: Gut microbiome of a multiethnic community possessed no predominant microbiota
Authors: Khine, Wei Wei Thwe 
Teo, Anna Hui Ting
Loong, Lucas Wee Wei
Tan, Jarett Jun Hao
Ang, Clarabelle Geok Hui
Ng, Winnie
Lee, Chuen Neng 
Zhu, Congju
Lau, Quek Choon
Lee, Yuan-Kun 
Keywords: Cytokines
Dietary habits
Faecal microbiome
Immune response
Multicultural dietary habit
Probiotics
Issue Date: 29-Mar-2021
Publisher: MDPI AG
Citation: Khine, Wei Wei Thwe, Teo, Anna Hui Ting, Loong, Lucas Wee Wei, Tan, Jarett Jun Hao, Ang, Clarabelle Geok Hui, Ng, Winnie, Lee, Chuen Neng, Zhu, Congju, Lau, Quek Choon, Lee, Yuan-Kun (2021-03-29). Gut microbiome of a multiethnic community possessed no predominant microbiota. Microorganisms 9 (4) : 702. ScholarBank@NUS Repository. https://doi.org/10.3390/microorganisms9040702
Rights: Attribution 4.0 International
Abstract: With increasing globalisation, various diets from around the world are readily available in global cities. This study aimed to verify if multiethnic dietary habits destabilised the gut mi-crobiome in response to frequent changes, leading to readily colonisation of exogenous microbes. This may have health implications. We profiled Singapore young adults of different ethnicities for dietary habits, faecal type, gut microbiome and cytokine levels. Subjects were challenged with Lactobacillus casei, and corresponding changes in microbiome and cytokines were evaluated. Here, we found that the majority of young adults had normal stool types (73% Bristol Scale Types 3 and 4) and faecal microbiome categorised into three clusters, irrespective of race and gender. Cluster 1 was dominated by Bacteroides, Cluster 2 by Prevotella, while Cluster 3 showed a marginal increase in Blautia, Ruminococaceae and Ruminococcus, without a predominant microbiota. These youngsters in the three faecal microbiome clusters preferred Western high sugary beverages, Southeast Asian plant-rich diet and Asian/Western diets in rotation, respectively. Multiethnic dietary habits (Cluster 3) led to a gut microbiome without predominant microbiota yet demonstrated colonisation resistance to Lactobacillus. Although Bacteroides and Prevotella are reported to be health-promoting but also risk factors for some illnesses, Singapore-style dietary rotation habits may alleviate Bacteroides and Prevotella associated ill effects. Different immunological outcome was observed during consumption of the lactobacilli among the three microbiome clusters. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Microorganisms
URI: https://scholarbank.nus.edu.sg/handle/10635/232496
ISSN: 2076-2607
DOI: 10.3390/microorganisms9040702
Rights: Attribution 4.0 International
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