Please use this identifier to cite or link to this item: https://doi.org/10.18632/aging.202705
Title: Effects of multi-domain lifestyle interventions on sarcopenia measures and blood biomarkers: secondary analysis of a randomized controlled trial of community-dwelling pre-frail and frail older adults
Authors: Lu, Y.
Niti, M.
Yap, K.B.
Tan, C.T.Y.
Ma, Shwe Zin Nyunt 
Feng, Liang 
Yeow Tan, B.
Chan, G.
Khoo, S.A.
Chan, S.M.
Yap, P.
Larbi, A.
Ng Tze Pin 
Keywords: homeostasis
inflammation
lifestyle intervention
randomized controlled trial
sarcopenia
Issue Date: 19-Mar-2021
Publisher: Impact Journals LLC
Citation: Lu, Y., Niti, M., Yap, K.B., Tan, C.T.Y., Ma, Shwe Zin Nyunt, Feng, Liang, Yeow Tan, B., Chan, G., Khoo, S.A., Chan, S.M., Yap, P., Larbi, A., Ng Tze Pin (2021-03-19). Effects of multi-domain lifestyle interventions on sarcopenia measures and blood biomarkers: secondary analysis of a randomized controlled trial of community-dwelling pre-frail and frail older adults. Aging 13 (7) : 9330-9347. ScholarBank@NUS Repository. https://doi.org/10.18632/aging.202705
Rights: Attribution 4.0 International
Abstract: Few studies have comprehensively described changes in blood biomarkers of the physiological responses underlying sarcopenia reduction associated with lifestyle interventions. In this study, we performed secondary analyses of data in a randomized controlled trial of multi-domain lifestyle interventions (6-month duration physical exercise, nutritional enrichment, cognitive training, combination and standard care control) among 246 community-dwelling pre-frail and frail elderly, aged ?65 years, with and without sarcopenia. Appendicular lean mass (ALM), lower limb strength, gait speed, and blood levels of markers of muscle metabolism, inflammation, anti-oxidation, anabolic hormone regulation, insulin signaling, tissue oxygenation were measured at baseline, 3-month and 6-month post-intervention. Multi-domain interventions were associated with significant (p & 0.001) reduction of sarcopenia at 3-month and 6-month post-intervention, improved gait speed, enhanced lower limb strength, and were equally evident among sarcopenic participants who were slower at baseline than non-sarcopenic participants. Active intervention was associated with significantly reduced inflammation levels. Sarcopenia status and reduction were associated with blood biomarkers related to muscle metabolism, steroid hormone regulation, insulin-leptin signaling, and tissue oxygenation. Physical, nutritional and cognitive intervention was associated with measures of sarcopenia reduction, together with changes in circulating biomarkers of anabolic and catabolic metabolism underlying sarcopenia. © 2021 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: Aging
URI: https://scholarbank.nus.edu.sg/handle/10635/232484
ISSN: 1945-4589
DOI: 10.18632/aging.202705
Rights: Attribution 4.0 International
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